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Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment

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Authors
Shen, Chenghua; Kim, Jae-hwan; Lee, Jeong-Keum; Bae, Young Mee; Choi, Min-Ho; Oh, Jin-Kyoung; Lim, Min Kyung; Shin, Hai-Rim; Hong, Sung-Tae
Issue Date
2007-06-16
Publisher
Korean Society for Parasitology
Citation
Korean J Parasitol. 2007 Jun;45(2):149-52.
Keywords
AdultAgedAged, 80 and overAnimalsAntiplatyhelmintic Agents/*therapeutic useClonorchiasis/*drug therapy/epidemiology/*parasitologyClonorchis sinensis/anatomy & histology/*isolation & purificationFeces/parasitologyFemaleHumansKorea/epidemiologyMaleMiddle AgedNeoplasms/epidemiologyParasite Egg CountPraziquantel/*therapeutic useRisk Factors
Abstract
A cohort was established for evaluation of cancer risk factors in Sancheong-gun, Gyeongsangnam-do, Korea. As one of the cohort studies, stools of 947 residents (403 males and 544 females, age range: 29-86 years) were screened for Clonorchis sinensis eggs using both Kato-Katz method and formalin-ether sedimentation technique. The overall egg positive rate of C. sinensis was 37.7% and individual EPG (eggs per gram of feces) counts ranged from 24 to 28,800. Eight egg positive residents voluntarily joined a process of collection of the passed worms after praziquantel treatment. A total of 158 worms were recovered from 5 of the 8 treated persons, ranged from 3 to 108 in each individual. The worms were 15-20 mm x 2-3 mm in size, and showed brown-pigmented, red, or white body colors. This is the first collection record of C. sinensis adult worms from humans through anthelmintic treatment and purgation. The adult worms of C. sinensis may be paralyzed by praziquantel and then discharged passively through bile flow in the bile duct and by peristaltic movement of the bowel.
ISSN
0023-4001 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17570980

https://hdl.handle.net/10371/29385
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College of Medicine/School of Medicine (의과대학/대학원)Parasitology and Tropical Medicine (기생충학전공)Journal Papers (저널논문_기생충학전공)
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