S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Activity of left inferior frontal gyrus related to word repetition effects: LORETA imaging with 128-channel EEG and individual MRI
- Kim, Young Youn; Lee, Boreom; Shin, Yong Wook; Kwon, Jun Soo; Kim, Myung-Sun
- Issue Date
- Neuroimage. 2006 Feb 1;29(3):712-20. Epub 2005 Sep 26.
- Adult; Brain Mapping; Data Interpretation, Statistical; Decision Making/physiology; Discrimination (Psychology)/physiology; *Electroencephalography; Female; Frontal Lobe/*physiology; Humans; *Magnetic Resonance Imaging; Male; Psycholinguistics; Psychomotor Performance/physiology; Reaction Time/physiology; Verbal Behavior/*physiology
- We investigated the brain substrate of word repetition effects on the implicit memory task using low-resolution electromagnetic tomography (LORETA) with high-density 128-channel EEG and individual MRI as a realistic head model. Thirteen right-handed, healthy subjects performed a word/non-word discrimination task, in which the words and non-words were presented visually, and some of the words appeared twice with a lag of one or five items. All of the subjects exhibited word repetition effects with respect to the behavioral data, in which a faster reaction time was observed to the repeated word (old word) than to the first presentation of the word (new word). The old words elicited more positive-going potentials than the new words, beginning at 200 ms and lasting until 500 ms post-stimulus. We conducted source reconstruction using LORETA at a latency of 400 ms with the peak mean global field potentials and used statistical parametric mapping for the statistical analysis. We found that the source elicited by the old words exhibited a statistically significant current density reduction in the left inferior frontal gyrus. This is the first study to investigate the generators of word repetition effects using voxel-by-voxel statistical mapping of the current density with individual MRI and high-density EEG.
- 1053-8119 (Print)
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