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Microarray analysis of thyroid stimulating hormone, insulin-like growth factor-1, and insulin-induced gene expression in FRTL-5 thyroid cells

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Authors
Lee, You Jin; Park, Do Joon; Shin, Chan Soo; Park, Kyong Soo; Kim, Seong Yeon; Lee, Hong Kyu; Park, Young Joo; Cho, Bo Youn
Issue Date
2007-11-06
Publisher
Korean Academy of Medical Science
Citation
J Korean Med Sci. 2007 Oct;22(5):883-90.
Keywords
AnimalsBone Morphogenetic Protein 6Bone Morphogenetic Proteins/biosynthesisCell Line, TumorCyclin D1/biosynthesis*Gene Expression Profiling*Gene Expression RegulationInsulin/*biosynthesis/metabolismInsulin-Like Growth Factor I/*biosynthesisModels, Genetic*Oligonucleotide Array Sequence AnalysisRatsReceptors, Glucagon/biosynthesisThyroid Gland/*metabolismThyrotropin/*biosynthesis/metabolismTime Factors
Abstract
To determine which genes are regulated by thyroid stimulating hormone (thyrotropin, TSH), insulin and insulin-like growth factor-1 (IGF-1) in the rat thyroid, we used the microarray technology and observed the changes in gene expression. The expressions of genes for bone morphogenetic protein 6, the glucagon receptor, and cyclin D1 were increased by both TSH and IGF-1; for cytochrome P450, 2c37, the expression was decreased by both. Genes for cholecystokinin, glucuronidase, beta, demethyl-Q 7, and cytochrome c oxidase, subunit VIIIa, were up-regulated; the genes for ribosomal protein L37 and ribosomal protein L4 were down-regulated by TSH and insulin. However, there was no gene observed to be regulated by all three: TSH, IGF-1, and insulin molecules studied. These findings suggest that TSH, IGF-1, and insulin stimulate different signal pathways, which can interact with one another to regulate the proliferation of thyrocytes, and thereby provide additional influence on the process of cellular proliferation.
ISSN
1011-8934 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17982240

http://hdl.handle.net/10371/29483
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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