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Identification of a novel role of T cells in postnatal vasculogenesis: characterization of endothelial progenitor cell colonies
DC Field | Value | Language |
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dc.contributor.author | Hur, Jin | - |
dc.contributor.author | Yang, Han-Mo | - |
dc.contributor.author | Yoon, Chang-Hwan | - |
dc.contributor.author | Lee, Choon-Soo | - |
dc.contributor.author | Park, Kyung-Woo | - |
dc.contributor.author | Kim, Ji-Hyun | - |
dc.contributor.author | Kim, Tae-Youn | - |
dc.contributor.author | Kim, Ju-Young | - |
dc.contributor.author | Kang, Hyun-Jae | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Oh, Byung-Hee | - |
dc.contributor.author | Park, Young-Bae | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2010-01-12T01:51:55Z | - |
dc.date.available | 2010-01-12T01:51:55Z | - |
dc.date.issued | 2007-10-03 | - |
dc.identifier.citation | Circulation. 2007 Oct 9;116(15):1671-82. Epub 2007 Oct 1. | en |
dc.identifier.issn | 1524-4539 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17909106 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29533 | - |
dc.description.abstract | BACKGROUND: The colony number of early endothelial progenitor cells (EPCs) has been used as a quantitative indicator of the number of EPCs in the blood or as a biological marker of cardiovascular diseases. In the present study, we found a subset of T cells that were localized at the center of the EPC colony and played a pivotal role in colony formation and differentiation of early EPCs. METHODS AND RESULTS: We found that CD3+ CD31+ CXCR4+ T cells (referred to as angiogenic T cells in the present study) constituted the center of EPC colonies during cultures of human peripheral blood mononuclear cells. These angiogenic T cells were required for colony formation and differentiation of early EPCs. They secreted high levels of angiogenic cytokines such as vascular endothelial growth factor, interleukin-8, and matrix metalloproteinases. Angiogenic T cells showed superior angiogenic potential to the other subset of T cells in the experiments with regard to Matrigel tube formation, adhesion, transendothelial migration, and collagen invasion assay, mainly through the stromal cell-derived factor 1/CXCR-4 axis. Furthermore, angiogenic T cells enhanced endothelial cell proliferation and function. In vivo study showed that angiogenic T cells play an important role in the process of vessel formation. Clinical study showed that the level of angiogenic T cells in the peripheral blood was well correlated with EPC colony numbers and had inverse relationships with age and the number of risk factors for coronary artery disease. CONCLUSIONS: These findings suggest that angiogenic T cells could be a potential therapeutic target for ischemic cardiovascular diseases. | en |
dc.language.iso | en | en |
dc.publisher | American Heart Association | en |
dc.subject | Antigens, CD/analysis | en |
dc.subject | Antigens, CD3/analysis | en |
dc.subject | Antigens, CD31/analysis | en |
dc.subject | Biological Markers | en |
dc.subject | Cardiovascular Diseases/*pathology | en |
dc.subject | Cell Differentiation | en |
dc.subject | Endothelium, Vascular/*growth & development/physiology | en |
dc.subject | Humans | en |
dc.subject | Neovascularization, Physiologic | en |
dc.subject | Stem Cells/cytology/immunology/*physiology | en |
dc.subject | T-Lymphocytes/cytology/immunology/*physiology | en |
dc.title | Identification of a novel role of T cells in postnatal vasculogenesis: characterization of endothelial progenitor cell colonies | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 허진 | - |
dc.contributor.AlternativeAuthor | 양한모 | - |
dc.contributor.AlternativeAuthor | 윤창환 | - |
dc.contributor.AlternativeAuthor | 이춘수 | - |
dc.contributor.AlternativeAuthor | 박경우 | - |
dc.contributor.AlternativeAuthor | 김지현 | - |
dc.contributor.AlternativeAuthor | 김태윤 | - |
dc.contributor.AlternativeAuthor | 김주영 | - |
dc.contributor.AlternativeAuthor | 강현재 | - |
dc.contributor.AlternativeAuthor | 채인호 | - |
dc.contributor.AlternativeAuthor | 오병희 | - |
dc.contributor.AlternativeAuthor | 박영배 | - |
dc.contributor.AlternativeAuthor | 김효수 | - |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.107.694778 | - |
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