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Increased white matter hyperintensities in male methamphetamine abusers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Soojeong C | - |
dc.contributor.author | Lyoo, In Kyoon | - |
dc.contributor.author | Sung, Young Hoon | - |
dc.contributor.author | Yoo, Jaeun | - |
dc.contributor.author | Chung, Ain | - |
dc.contributor.author | Yoon, Su-Jung | - |
dc.contributor.author | Kim, Dai-Jin | - |
dc.contributor.author | Hwang, Jaeuk | - |
dc.contributor.author | Kim, Seog Ju | - |
dc.contributor.author | Renshaw, Perry F | - |
dc.date.accessioned | 2010-01-12T01:57:27Z | - |
dc.date.available | 2010-01-12T01:57:27Z | - |
dc.date.issued | 2005-07-12 | - |
dc.identifier.citation | Drug Alcohol Depend. 2006 Jan 4;81(1):83-8. Epub 2005 Jul 6. | en |
dc.identifier.issn | 0376-8716 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T63-4GJVB5D-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b3351ec22a3b9a2f477a7d23d83dc4ae | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16005161 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29544 | - |
dc.description.abstract | BACKGROUND: The current study was conducted to compare the prevalence, severity, and location of white matter signal hyperintensities (WMH) on brain magnetic resonance (MR) imaging in methamphetamine (MA) abusers. METHODS: Thirty-three MA abusers and 32 age- and gender-matched healthy comparison subjects were studied. Axial T-2 weighted images and fluid attenuated inversion recovery axial images were obtained using 3.0 T MR scanner. The severity of WMH was assessed separately for deep and periventricular WMH. Ordinal logistic regression models were used to assess the odds ratio for WMH. RESULTS: MA abusers had greater severity of WMH than the healthy comparison subjects (odds ratio: 7.06, 8.46, and 4.56 for all, deep, and periventricular WMH, respectively). Severity of deep WMH correlated with total cumulative dose of MA (p = 0.027). Male MA abusers had greater severity of WMH than female MA abusers (odds ratio = 10.00). While male MA abusers had greater severity of WMH than male comparison subjects (odds ratio = 18.86), there was no significant difference in WMH severity between female MA abusers and female comparison subjects. CONCLUSIONS: The current study reports increased WMH in MA abusers, which may be related to MA-induced cerebral perfusion deficits. In addition, female MA abusers had less severe WMH than male MA abusers, possibly due to estrogen's protective effect against ischemic or neurotoxic effects of MA. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Amphetamine-Related Disorders/*pathology | en |
dc.subject | Brain/pathology | en |
dc.subject | Cerebral Ventricles/pathology | en |
dc.subject | Dementia, Vascular/*chemically induced/pathology | en |
dc.subject | Demyelinating Diseases/*chemically induced/pathology | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Methamphetamine/*toxicity | en |
dc.subject | Midline Thalamic Nuclei/pathology | en |
dc.subject | Neurotoxicity Syndromes/*pathology | en |
dc.subject | Reference Values | en |
dc.subject | Risk Factors | en |
dc.subject | Statistics as Topic | en |
dc.subject | Magnetic Resonance Imaging | - |
dc.title | Increased white matter hyperintensities in male methamphetamine abusers | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 배수정 | - |
dc.contributor.AlternativeAuthor | 류인균 | - |
dc.contributor.AlternativeAuthor | 성영훈 | - |
dc.contributor.AlternativeAuthor | 유재은 | - |
dc.contributor.AlternativeAuthor | 정아인 | - |
dc.contributor.AlternativeAuthor | 윤수정 | - |
dc.contributor.AlternativeAuthor | 김대진 | - |
dc.contributor.AlternativeAuthor | 황재욱 | - |
dc.contributor.AlternativeAuthor | 김석주 | - |
dc.identifier.doi | 10.1016/j.drugalcdep.2005.05.016 | - |
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