Publications
Detailed Information
Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study
Cited 117 time in
Web of Science
Cited 126 time in Scopus
- Authors
- Issue Date
- 2007-07-25
- Publisher
- American Association for Cancer Research
- Citation
- Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1581-6. Epub 2007 Jul 23.
- Keywords
- Aged ; Alanine/genetics ; Alleles ; Antioxidants/administration & dosage ; Case-Control Studies ; Diet ; European Continental Ancestry Group/genetics ; Exons/genetics ; Genetic Variation/*genetics ; Humans ; Isoenzymes/genetics ; Male ; Middle Aged ; Polymorphism, Genetic/*genetics ; Prostatic Neoplasms/*enzymology/genetics ; Risk Factors ; Smoking/adverse effects ; Superoxide Dismutase/*genetics ; Valine/genetics ; Vitamin E/administration & dosage ; Free Radical Scavengers
- Abstract
- Superoxide dismutase (SOD) plays a key role in the detoxification of superoxide free radicals. We evaluated the association of prostate cancer with genetic polymorphisms in SOD1 (CuZn-SOD; IVS3-251A>G), SOD2 [MnSOD; Ex2+24T>C (V16A)], and SOD3 (EC-SOD; IVS1+186C>T, Ex3-631C>G, Ex3-516C>T, and Ex3-489C>T), the three main isoforms of SOD. Prostate cancer cases (n = 1,320) from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial were frequency matched to nondiseased controls (n = 1,842) by age, race, time since initial screening, and year of blood draw. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI); stratified analysis by the level of antioxidative vitamins was also conducted. The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03). Stratification by quartiles of dietary and supplemental vitamin E intake (IU/d) showed risks of prostate cancer tended to be increased among SOD2 Ala allele carriers, except at the highest quartile of vitamin E intake (>222; P(interaction) = 0.06, Q1-Q3 versus Q4). The association between Ala allele and prostate cancer risk among those with lower intake of vitamin E (
- ISSN
- 1055-9965 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17646272
https://hdl.handle.net/10371/29576
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.