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Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study

Cited 107 time in Web of Science Cited 110 time in Scopus
Authors
Kang, Daehee; Lee, Kyoung-Mu; Park, Sue Kyung; Berndt, Sonja I; Peters, Ulrike; Reding, Douglas; Chatterjee, Nilanjan; Welch, Robert; Chanock, Stephen; Huang, Wen-Yi; Hayes, Richard B
Issue Date
2007-07-25
Publisher
American Association for Cancer Research
Citation
Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1581-6. Epub 2007 Jul 23.
Keywords
AgedAlanine/geneticsAllelesAntioxidants/administration & dosageCase-Control StudiesDietEuropean Continental Ancestry Group/geneticsExons/genetics*Free Radical ScavengersGenetic Variation/*geneticsHumansIsoenzymes/geneticsMaleMiddle AgedPolymorphism, Genetic/*geneticsProstatic Neoplasms/*enzymology/geneticsRisk FactorsSmoking/adverse effectsSuperoxide Dismutase/*geneticsValine/geneticsVitamin E/administration & dosage
Abstract
Superoxide dismutase (SOD) plays a key role in the detoxification of superoxide free radicals. We evaluated the association of prostate cancer with genetic polymorphisms in SOD1 (CuZn-SOD; IVS3-251A>G), SOD2 [MnSOD; Ex2+24T>C (V16A)], and SOD3 (EC-SOD; IVS1+186C>T, Ex3-631C>G, Ex3-516C>T, and Ex3-489C>T), the three main isoforms of SOD. Prostate cancer cases (n = 1,320) from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial were frequency matched to nondiseased controls (n = 1,842) by age, race, time since initial screening, and year of blood draw. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI); stratified analysis by the level of antioxidative vitamins was also conducted. The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03). Stratification by quartiles of dietary and supplemental vitamin E intake (IU/d) showed risks of prostate cancer tended to be increased among SOD2 Ala allele carriers, except at the highest quartile of vitamin E intake (>222; P(interaction) = 0.06, Q1-Q3 versus Q4). The association between Ala allele and prostate cancer risk among those with lower intake of vitamin E (
ISSN
1055-9965 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17646272

http://hdl.handle.net/10371/29576
DOI
https://doi.org/10.1158/1055-9965.EPI-07-0160
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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