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Outcome of vancomycin treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sung-Han | - |
dc.contributor.author | Kim, Kye-Hyung | - |
dc.contributor.author | Kim, Hong-Bin | - |
dc.contributor.author | Kim, Nam-Joong | - |
dc.contributor.author | Kim, Eui-Chong | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Choe, Kang-Won | - |
dc.date.accessioned | 2010-01-12T05:02:49Z | - |
dc.date.available | 2010-01-12T05:02:49Z | - |
dc.date.issued | 2007-11-07 | - |
dc.identifier.citation | Antimicrob Agents Chemother. 2008 Jan;52(1):192-7. Epub 2007 Nov 5. | en |
dc.identifier.issn | 0066-4804 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17984229 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29675 | - |
dc.description.abstract | Limited data on the clinical outcome of vancomycin treatment compared with that of beta-lactam treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia (MSSA-B) are available. We used different and complementary approaches: (i) a retrospective cohort study using a propensity score to adjust for confounding by treatment assignment and (ii) a matched case-control study. Of all patients with S. aureus bacteremia (SAB) in two university-affiliated hospitals over a 7-year period, 294 patients with MSSA-B were enrolled in the cohort study. The cases for the case-control study were defined as patients who received vancomycin treatment for MSSA-B; the controls, who were patients that received beta-lactam treatment for MSSA-B, were selected at a 1:2 (case:control) ratio according to the objective matching scoring system and the propensity score system. In the cohort study, SAB-related mortality in patients with vancomycin treatment (37%, 10/27) was significantly higher than that in those with beta-lactam treatment (18%, 47/267) (P = 0.02). In addition, multivariate analysis revealed that vancomycin treatment was associated with SAB-related mortality when independent predictors for SAB-related mortality and propensity score were considered (adjusted odds ratio of 3.3, 95% confidence interval of 1.2 to 9.5). In the case-control study using the objective matching scoring system and the propensity score system, SAB-related mortality in case patients was 37% (10/27) and in control patients 11% (6/54) (P < 0.01). Our data suggest that vancomycin is inferior to beta-lactam in the treatment of MSSA-B. | en |
dc.language.iso | en | en |
dc.publisher | American Society for Microbiology | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Anti-Bacterial Agents/*pharmacology/*therapeutic use | en |
dc.subject | Bacteremia/*drug therapy/microbiology/mortality | en |
dc.subject | Case-Control Studies | en |
dc.subject | Cohort Studies | en |
dc.subject | Female | en |
dc.subject | Hospitals, University | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Methicillin/*pharmacology/therapeutic use | en |
dc.subject | Microbial Sensitivity Tests | en |
dc.subject | Middle Aged | en |
dc.subject | Staphylococcal Infections/drug therapy/microbiology/mortality | en |
dc.subject | Staphylococcus aureus/*drug effects | en |
dc.subject | Treatment Outcome | en |
dc.subject | Vancomycin/*therapeutic use | en |
dc.subject | beta-Lactams/pharmacology/therapeutic use | en |
dc.title | Outcome of vancomycin treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김성한 | - |
dc.contributor.AlternativeAuthor | 김계형 | - |
dc.contributor.AlternativeAuthor | 김홍빈 | - |
dc.contributor.AlternativeAuthor | 김남중 | - |
dc.contributor.AlternativeAuthor | 김의종 | - |
dc.contributor.AlternativeAuthor | 오명돈 | - |
dc.contributor.AlternativeAuthor | 최강원 | - |
dc.identifier.doi | 10.1128/AAC.00700-07 | - |
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