Browse

Effects of intravascular volume therapy using hydroxyethyl starch (130/0.4) on post-operative bleeding and transfusion requirements in children undergoing cardiac surgery: a randomized clinical trial

Cited 46 time in Web of Science Cited 50 time in Scopus
Authors
Kim, Chong Sung; Park, Kum Suk; Yoon, Mi Ja; Kim, Kyoung Ok
Issue Date
2006-02-03
Publisher
Munksgaard
Citation
Acta Anaesthesiol Scand. 2006 Jan;50(1):108-11.
Keywords
*Blood Transfusion*Cardiac Surgical ProceduresCardiopulmonary BypassChildChild, PreschoolHeart Defects, Congenital/surgeryHetastarch/*administration & dosageHumansInfantInternational Normalized RatioMolecular WeightPartial Thromboplastin TimePlasmaPlasma Substitutes/*administration & dosagePostoperative CarePostoperative Hemorrhage/*therapy
Abstract
BACKGROUND: Hydroxyethyl starch (HES) used for intravascular volume expansion may cause coagulation abnormalities, especially in cardiac patients. Although low molecular weight HES (130/0.4) has been developed to minimize its influence on coagulation, experience with HES (130/0.4) in children is limited. Therefore, we evaluated the effects of a HES (130/0.4) infusion on post-operative blood loss in children undergoing cardiac surgery. METHODS: Forty-two children undergoing cardiac surgery were assigned at random to receive either 10 ml/kg fresh frozen plasma (FFP group; n=21) or HES (130/0.4) (HES group; n=21) shortly after cardiopulmonary bypass termination. Activated partial thromboplastin time (aPTT) and international normalization ratio (INR) were measured. In addition, post-operative transfusion requirements and blood loss until the end of the first post-operative day were compared. RESULTS: INR was significantly prolonged after HES infusion in comparison to the FFP group (P<0.05). During the first 24 h after surgery, post-operative blood loss, the use of allogenic blood/blood products and aPTT were similar in all children. CONCLUSIONS: Our study shows that the administration of a moderate dose of HES (130/0.4) in children undergoing cardiac surgery does not cause more bleeding or a higher transfusion requirement than a FFP infusion, and suggests that the administration of 10 ml/kg HES (130/0.4) is a safe alternative to plasma for intravascular volume replacement in this patient population.
ISSN
0001-5172 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16451158

http://hdl.handle.net/10371/29700
DOI
https://doi.org/10.1111/j.1399-6576.2005.00881.x
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Anesthesiology and Pain Medicine (마취통증의학전공)Journal Papers (저널논문_마취통증의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse