Browse

Effects of stem cell therapy with G-CSF on coronary artery after drug-eluting stent implantation in patients with acute myocardial infarction

Cited 9 time in Web of Science Cited 10 time in Scopus
Authors
Kang, H-J; Kim, Y-S; Koo, B-K; Park, K W; Lee, H-Y; Sohn, D-W; Oh, B-H; Park, Y-B; Kim, H-S
Issue Date
2007-12-12
Publisher
BMJ Publishing Group
Citation
Heart. 2008 May;94(5):604-9. Epub 2007 Dec 10.
Keywords
Angioplasty, Transluminal, Percutaneous CoronaryCoronary Angiography/methodsCoronary Artery Disease/drug therapy/*metabolism/surgeryCoronary Vessels/*drug effects*Drug-Eluting StentsFemaleGranulocyte Colony-Stimulating Factor/*therapeutic useHumansMaleMiddle AgedMyocardial Infarction/*therapyPaclitaxel/administration & dosagePeripheral Blood Stem Cell Transplantation/*methodsSirolimus/administration & dosageTreatment OutcomeTubulin Modulators/administration & dosageUltrasonography, Interventional/methods
Abstract
OBJECTIVE: The effects of stem cell therapy on the coronary vasculature were investigated in patients with acute myocardial infarction who underwent peripheral blood stem cell (PBSC) therapy in the MAGIC Cell-3-DES study. METHODS: Among 50 patients with acute myocardial infarction who underwent either sirolimus-eluting stent or paclitaxel-eluting stent implantation for the culprit lesion, intravascular ultrasound was analysed in 36 patients (cell infusion: n = 19 and control: n = 17). In the cell infusion group, PBSCs mobilised by granulocyte-colony stimulating factor were delivered via intracoronary infusion into infarcted myocardium. Proximal and distal reference segments, and stented segments, were evaluated with intravascular ultrasound at immediate post-intervention and 6-month follow-up, respectively. RESULTS: In the proximal and distal reference segments, the serial changes of lumen area, vessel area, and plaque plus media area were not significantly different between the cell infusion and the control groups. Within stented segments, mean neointimal area was similar in the two groups (cell infusion: 0.2 (SD 0.5) mm(2) vs control: 0.3 (SD 0.4) mm(2), p>0.05). However, there was a significant increase in mean peri-stent area of stented segment in the cell infusion group compared with the control group (0.7 (SD 1.4) mm(2) vs -0.1 (SD 1.2) mm(2), p<0.05). This difference mainly came from paclitaxel-eluting stent-implanted patients. CONCLUSION: Intracoronary infusion of PBSCs mobilised with G-CSF does not aggravate de novo atherosclerotic lesion and neointimal hyperplasia with DES implantation. However, it may induce peri-stent tissue growth at the stented segment, especially in patients receiving PES. Its clinical significance needs to be evaluated with long-term follow-up.
ISSN
1468-201X (Electronic)
Language
English
URI
http://heart.bmj.com/cgi/content/abstract/94/5/604

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18070947

https://hdl.handle.net/10371/29715
DOI
https://doi.org/10.1136/hrt.2007.128348
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse