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Prognostic factors for surgical resection in patients with multidrug-resistant tuberculosis

Cited 43 time in Web of Science Cited 52 time in Scopus
Authors
Kim, H J; Kang, C H; Kim, Y T; Sung, S-W; Kim, J H; Lee, S M; Yoo, C-G; Lee, C-T; Kim, Y W; Han, S K; Shim, Y-S; Yim, J-J
Issue Date
2006-05-19
Publisher
European Respiratory Society
Citation
Eur Respir J. 2006 Sep;28(3):576-80. Epub 2006 May 17.
Keywords
AdultAgedBody Mass IndexBiological MarkersDrug Resistance, Multiple, BacterialFemaleHumansLung/microbiology/surgeryMaleMiddle AgedMycobacterium tuberculosis/drug effects/isolation & purificationOfloxacin/pharmacologyPrognosisTreatment OutcomeTuberculosis, Multidrug-Resistant/*diagnosis/*surgeryTuberculosis, Pulmonary/*diagnosis/*surgery
Abstract
Although surgical lung resection could improve prognosis in some patients with multidrug-resistant tuberculosis (MDR-TB), there are no reports on the optimal candidates for this surgery. The aim of the present study was to elucidate the prognostic factors for surgery in patients with MDR-TB. Patients who underwent lung resection for the treatment of MDR-TB between March 1993 and December 2004 were included in the present study. Treatment failure was defined as greater than or equal to two of the five cultures recorded in the final 12 months of treatment being positive, any one of the final three cultures being positive, or the patient having died during treatment. The variables that affected treatment outcomes were identified through univariate and multivariate logistic regression analysis. In total, 79 patients with MDR-TB were included in the present study. The treatment outcomes of 22 (27.8%) patients were classified as failure. A body mass index <18.5 kg x m(-2), primary resistance, resistance to ofloxacin and the presence of a cavitary lesion beyond the range of the surgical resection were associated with treatment failure. Low body mass index, primary resistance, resistance to ofloxacin and cavitary lesions beyond the range of resection are possible poor prognostic factors for surgical lung resection in multidrug-resistant tuberculosis patients.
ISSN
0903-1936 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16707517

http://hdl.handle.net/10371/29743
DOI
https://doi.org/10.1183/09031936.06.00023006
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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