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Baicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in mice

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dc.contributor.authorIm, Heh-In-
dc.contributor.authorJoo, Wan Seok-
dc.contributor.authorNam, Eunjoo-
dc.contributor.authorLee, Eun-sun-
dc.contributor.authorHwang, Yu-jin-
dc.contributor.authorKim, Yong Sik-
dc.date.accessioned2010-01-12T06:55:42Z-
dc.date.available2010-01-12T06:55:42Z-
dc.date.issued2005-06-09-
dc.identifier.citationJ Pharmacol Sci. 2005 Jun;98(2):185-9. Epub 2005 Jun 8.en
dc.identifier.issn1347-8613 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15942123-
dc.identifier.urihttps://hdl.handle.net/10371/29744-
dc.description.abstractThe effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v. injection. Animals received further injection of bacalein daily for 3 consecutive days. Rotarod performance was assessed, tyrosine hydroxylase (TH) Western blotting was performed, and dopamine (DA) levels and peroxidation were determined. High dose of baicalein effectively improved rotarod performance and prevented the reduction of striatal DA levels and TH contents in the striatum and subtantia nigra (SN). In addition, lipid peroxidation level was decreased by baicalein at 3 and 7 days after 6-OHDA injection. These results showed that baicalein effectively prevents the 6-OHDA-induced dopaminergic dysfunction through an antioxidative action.en
dc.language.isoenen
dc.publisherJapanese Pharmacological Societyen
dc.subjectAnimalsen
dc.subjectDopamine/*physiologyen
dc.subjectFlavanones/*pharmacologyen
dc.subjectInjections, Intraventricularen
dc.subjectLipid Peroxidation/*drug effectsen
dc.subjectMiceen
dc.subjectNeuroprotective Agents/*pharmacologyen
dc.subjectOxidopamine/administration & dosage/*pharmacologyen
dc.subjectPsychomotor Performance/drug effectsen
dc.titleBaicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in miceen
dc.typeArticleen
dc.contributor.AlternativeAuthor임해인-
dc.contributor.AlternativeAuthor주완석-
dc.contributor.AlternativeAuthor남은주-
dc.contributor.AlternativeAuthor이은선-
dc.contributor.AlternativeAuthor황유진-
dc.contributor.AlternativeAuthor김용식-
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