Browse

Rhapontigenin from Rheum undulatum protects against oxidative-stress-induced cell damage through antioxidant activity

Cited 30 time in Web of Science Cited 29 time in Scopus
Authors
Zhang, Rui; Kang, Kyoung Ah; Piao, Mei Jing; Lee, Kyoung Hwa; Jang, Hye Suk; Park, Min Jeong; Kim, Bum Joon; Kim, Jin Sook; Kim, Young Sup; Hyun, Jin Won
Issue Date
2007-06-15
Publisher
Taylor & Francis
Citation
J Toxicol Environ Health A. 2007 Jul;70(13):1155-66.
Keywords
AnimalsAntioxidants/*pharmacologyApoptosis/drug effectsCatalase/metabolismCricetinaeCricetulusDNA Damage/drug effectsExtracellular Signal-Regulated MAP Kinases/metabolismFibroblasts/drug effects/physiologyGene Expression/drug effectsHydrogen PeroxideLipid PeroxidationLung/cytologyOxidative Stress/*drug effectsPhosphorylationPlant Extracts/*pharmacologyReactive Oxygen Species/metabolismRheum/*chemistrySignal Transduction/drug effectsStilbenes/*pharmacology
Abstract
The antioxidant properties of rhapontigenin and rhaponticin isolated from Rheum undulatum were investigated. Rhapontigenin was found to scavenge intracellular reactive oxygen species (ROS), the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and hydrogen peroxide (H2O2). The radical scavenging effect of rhapontigenin was more effective than rhaponticin. Rhapontigenin protected against H2O2-induced membrane lipid peroxidation and cellular DNA damage, which are the main targets of oxidative stress-induced cellular damage. The radical scavenging activity of rhapontigenin protected Chinese hamster lung fibroblast (V79-4) cells exposed to H2O2 by inhibiting apoptosis. Rhapontigenin inhibited cell damage induced by serum starvation and was also found to increase the activity of catalase and its protein expression. Further, rhapontigenin increased phosphorylation of extracellular signal-regulated kinase (ERK) and inhibited the activity of activator protein 1 (AP-1), a redox-sensitive transcription factor. In summary, these results suggest that rhapontigenin protects V79-4 cells against oxidative damage by enhancing the cellular antioxidant activity and modulating cellular signal pathways.
ISSN
1528-7394 (Print)
Language
English
URI
http://www.informaworld.com/smpp/content~db=all?content=10.1080/15287390701252766

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17558811

http://hdl.handle.net/10371/29781
DOI
https://doi.org/10.1080/15287390701252766
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse