Publications
Detailed Information
Effects of the early administration of heparin in patients with ST-elevation myocardial infarction treated by primary angioplasty
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Woo-Young | - |
dc.contributor.author | Han, Mi-Jung | - |
dc.contributor.author | Cho, Young-Seok | - |
dc.contributor.author | Kim, Kwang-Il | - |
dc.contributor.author | Chang, Hyuk-Jai | - |
dc.contributor.author | Youn, Tae-Jin | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Choi, Dong-Ju | - |
dc.contributor.author | Kim, Cheol-Ho | - |
dc.contributor.author | Oh, Byung-Hee | - |
dc.contributor.author | Park, Young-Bae | - |
dc.contributor.author | Choi, Yun-Shik | - |
dc.date.accessioned | 2010-01-18T06:02:53Z | - |
dc.date.available | 2010-01-18T06:02:53Z | - |
dc.date.issued | 2007-05-29 | - |
dc.identifier.citation | Circ J. 2007 Jun;71(6):862-7. | en |
dc.identifier.issn | 1346-9843 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17526981 | - |
dc.identifier.uri | https://hdl.handle.net/10371/36740 | - |
dc.description.abstract | BACKGROUND: The effect of adjunctive heparin for primary angioplasty in patients with ST-elevation myocardial infarction (STEMI) is not well established, so the authors investigated the effect of early heparin administration in the emergency room (ER) on initial patency of the infarct-related artery (IRA) and on the clinical outcome in STEMI patients. METHODS AND RESULTS: One hundred and twenty consecutive patients who presented with STEMI less than 12 h from pain onset and who were eligible for primary percutaneous coronary intervention were allocated to an early heparin group (heparin administered in ER) or a late heparin group (heparin administered after angiography). In the early heparin group, unfractionated heparin (60 U/kg bolus IV, then 14 U . kg(-1) . h(-1) IV infusion) or enoxaparin (1 mg/kg bolus SC) were administered 144+/-95 min before angioplasty. No significant differences in baseline characteristics were observed between the early heparin group (n=56) and the late heparin group (n=64). However, initial Thrombolysis In Myocardial Infarction (TIMI) flow grade in the IRA was significantly different between the 2 groups (frequency of TIMI 0/1/2/3; 48/4/7/41% vs 70/8/11/11%, early vs late respectively, p=0.002). TIMI 2 or 3 flow was significantly more frequent in the early heparin group than in the late heparin group (48% vs 22%, p=0.002). However, no significant differences were noted between the 2 groups in terms of in-hospital major adverse cardiac events (7% vs 11%, p=0.472) and TIMI major bleeding (2% vs 3%, p=0.639). CONCLUSIONS: In STEMI patients, early heparin therapy administered in the ER improves coronary patency, despite not reaching clinical benefit. | en |
dc.language.iso | en | en |
dc.publisher | Unknown / The Japanese Circulation Society | en |
dc.subject | Anticoagulants/*administration & dosage | en |
dc.subject | Enoxaparin/*administration & dosage | en |
dc.subject | Female | en |
dc.subject | Heparin/*administration & dosage | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Myocardial Infarction/mortality/*therapy | en |
dc.subject | Retrospective Studies | en |
dc.subject | Treatment Outcome | en |
dc.subject | Angioplasty, Balloon | - |
dc.title | Effects of the early administration of heparin in patients with ST-elevation myocardial infarction treated by primary angioplasty | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정우영 | - |
dc.contributor.AlternativeAuthor | 한미정 | - |
dc.contributor.AlternativeAuthor | 조영석 | - |
dc.contributor.AlternativeAuthor | 김광일 | - |
dc.contributor.AlternativeAuthor | 장혁재 | - |
dc.contributor.AlternativeAuthor | 연태진 | - |
dc.contributor.AlternativeAuthor | 채인호 | - |
dc.contributor.AlternativeAuthor | 최동주 | - |
dc.contributor.AlternativeAuthor | 김철호 | - |
dc.contributor.AlternativeAuthor | 오병희 | - |
dc.contributor.AlternativeAuthor | 박영배 | - |
dc.contributor.AlternativeAuthor | 최윤식 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.