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Effects of the early administration of heparin in patients with ST-elevation myocardial infarction treated by primary angioplasty

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dc.contributor.authorChung, Woo-Young-
dc.contributor.authorHan, Mi-Jung-
dc.contributor.authorCho, Young-Seok-
dc.contributor.authorKim, Kwang-Il-
dc.contributor.authorChang, Hyuk-Jai-
dc.contributor.authorYoun, Tae-Jin-
dc.contributor.authorChae, In-Ho-
dc.contributor.authorChoi, Dong-Ju-
dc.contributor.authorKim, Cheol-Ho-
dc.contributor.authorOh, Byung-Hee-
dc.contributor.authorPark, Young-Bae-
dc.contributor.authorChoi, Yun-Shik-
dc.date.accessioned2010-01-18T06:02:53Z-
dc.date.available2010-01-18T06:02:53Z-
dc.date.issued2007-05-29-
dc.identifier.citationCirc J. 2007 Jun;71(6):862-7.en
dc.identifier.issn1346-9843 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17526981-
dc.identifier.urihttps://hdl.handle.net/10371/36740-
dc.description.abstractBACKGROUND: The effect of adjunctive heparin for primary angioplasty in patients with ST-elevation myocardial infarction (STEMI) is not well established, so the authors investigated the effect of early heparin administration in the emergency room (ER) on initial patency of the infarct-related artery (IRA) and on the clinical outcome in STEMI patients. METHODS AND RESULTS: One hundred and twenty consecutive patients who presented with STEMI less than 12 h from pain onset and who were eligible for primary percutaneous coronary intervention were allocated to an early heparin group (heparin administered in ER) or a late heparin group (heparin administered after angiography). In the early heparin group, unfractionated heparin (60 U/kg bolus IV, then 14 U . kg(-1) . h(-1) IV infusion) or enoxaparin (1 mg/kg bolus SC) were administered 144+/-95 min before angioplasty. No significant differences in baseline characteristics were observed between the early heparin group (n=56) and the late heparin group (n=64). However, initial Thrombolysis In Myocardial Infarction (TIMI) flow grade in the IRA was significantly different between the 2 groups (frequency of TIMI 0/1/2/3; 48/4/7/41% vs 70/8/11/11%, early vs late respectively, p=0.002). TIMI 2 or 3 flow was significantly more frequent in the early heparin group than in the late heparin group (48% vs 22%, p=0.002). However, no significant differences were noted between the 2 groups in terms of in-hospital major adverse cardiac events (7% vs 11%, p=0.472) and TIMI major bleeding (2% vs 3%, p=0.639). CONCLUSIONS: In STEMI patients, early heparin therapy administered in the ER improves coronary patency, despite not reaching clinical benefit.en
dc.language.isoenen
dc.publisherUnknown / The Japanese Circulation Societyen
dc.subject*Angioplasty, Balloonen
dc.subjectAnticoagulants/*administration & dosageen
dc.subjectEnoxaparin/*administration & dosageen
dc.subjectFemaleen
dc.subjectHeparin/*administration & dosageen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyocardial Infarction/mortality/*therapyen
dc.subjectRetrospective Studiesen
dc.subjectTreatment Outcomeen
dc.titleEffects of the early administration of heparin in patients with ST-elevation myocardial infarction treated by primary angioplastyen
dc.typeArticleen
dc.contributor.AlternativeAuthor정우영-
dc.contributor.AlternativeAuthor한미정-
dc.contributor.AlternativeAuthor조영석-
dc.contributor.AlternativeAuthor김광일-
dc.contributor.AlternativeAuthor장혁재-
dc.contributor.AlternativeAuthor연태진-
dc.contributor.AlternativeAuthor채인호-
dc.contributor.AlternativeAuthor최동주-
dc.contributor.AlternativeAuthor김철호-
dc.contributor.AlternativeAuthor오병희-
dc.contributor.AlternativeAuthor박영배-
dc.contributor.AlternativeAuthor최윤식-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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