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VDUP1 mediates nuclear export of HIF1alpha via CRM1-dependent pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Daesung | - |
dc.contributor.author | Jeon, Jun-Ho | - |
dc.contributor.author | Jeong, Mira | - |
dc.contributor.author | Suh, Hyun-Woo | - |
dc.contributor.author | Kim, Seyl | - |
dc.contributor.author | Kim, Hyoung-Chin | - |
dc.contributor.author | Moon, Og-Sung | - |
dc.contributor.author | Kim, Yong-Sung | - |
dc.contributor.author | Chung, Jin Woong | - |
dc.contributor.author | Yoon, Suk Ran | - |
dc.contributor.author | Kim, Woo-Ho | - |
dc.contributor.author | Choi, Inpyo | - |
dc.date.accessioned | 2009-05-22T05:29:53Z | - |
dc.date.available | 2009-05-22T05:29:53Z | - |
dc.date.issued | 2007-11-07 | - |
dc.identifier.citation | Biochim. Biophys. Acta 1783 (2008) 838-848 | en |
dc.identifier.issn | 0006-3002 | - |
dc.identifier.uri | https://hdl.handle.net/10371/3701 | - |
dc.description.abstract | Hypoxia-inducible factor 1alpha (HIF1alpha) is a critical transcriptional factor for inducing tumor metastasis, and stabilized under hypoxia but degraded by von Hippel-Lindau protein (pVHL) under normoxia. For the maximal degradation of HIF1alpha, it must be exported to the cytoplasm via an unidentified transporter. Here, we demonstrate that vitamin D3 up-regulated protein 1 (VDUP1) associates with the beta-domain of pVHL and enhances the interaction between pVHL and HIF1alpha to promote the nuclear export and degradation of HIF1alpha hypoxia-independently. Blocking of VDUP1 translocation either by leptomycin B or by nuclear export signal mutation inhibited the nuclear export of pVHL/HIF1alpha and relieved the destabilization of HIF1alpha. VDUP1 suppressed cell invasiveness and tumor metastasis, which were also recovered by blocking of nuclear export. Taken together, these findings indicate that VDUP1 is a novel tumor suppressor which mediates the nuclear export of pVHL/HIF1alpha complex to destabilize HIF1alpha. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | HIF1α | en |
dc.subject | pVHL | en |
dc.subject | VDUP1 | en |
dc.subject | CRM1 | en |
dc.subject | Transport | en |
dc.title | VDUP1 mediates nuclear export of HIF1alpha via CRM1-dependent pathway | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 신대성 | - |
dc.contributor.AlternativeAuthor | 전준호 | - |
dc.contributor.AlternativeAuthor | 정미라 | - |
dc.contributor.AlternativeAuthor | 서현우 | - |
dc.contributor.AlternativeAuthor | 김세일 | - |
dc.contributor.AlternativeAuthor | 김형진 | - |
dc.contributor.AlternativeAuthor | 문옥성 | - |
dc.contributor.AlternativeAuthor | 김용성 | - |
dc.contributor.AlternativeAuthor | 정진웅 | - |
dc.contributor.AlternativeAuthor | 윤석란 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.contributor.AlternativeAuthor | 최인표 | - |
dc.identifier.doi | 10.1016/j.bbamcr.2007.10.012 | - |
dc.citation.journaltitle | Biochimica et biophysica acta | - |
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