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Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial
Cited 199 time in
Web of Science
Cited 248 time in Scopus
- Authors
- Issue Date
- 2006-07-06
- Publisher
- American Heart Association
- Citation
- Circulation. 2006 Jul 4;114(1 Suppl):I145-51.
- Keywords
- Acute Disease ; Aged ; Angioplasty, Transluminal, Percutaneous Coronary ; Coronary Restenosis/*prevention & control ; Coronary Vessels ; Drug Implants ; Echocardiography, Doppler, Color ; Female ; Granulocyte Colony-Stimulating Factor/pharmacology ; Hematopoietic Stem Cell Mobilization ; Humans ; Hyperplasia ; Injections, Intra-Arterial ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Cine ; Male ; Middle Aged ; Myocardial Infarction/pathology/*surgery ; Peripheral Blood Stem Cell Transplantation/*methods ; Stents ; Stroke Volume ; Transplantation, Autologous ; Treatment Outcome ; Tunica Intima/pathology ; Ventricular Function, Left ; Ventricular Remodeling
- Abstract
- BACKGROUND: The efficacy of intracoronary infusion of granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) has not been compared between patients with acute (AMI) versus old myocardial infarction (OMI). In addition, the potential risk of restenosis associated with G-CSF-based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation. METHODS AND RESULTS: We randomly allocated 96 patients with myocardial infarction who underwent coronary revascularization with DES for the culprit lesion into 4 groups. Eighty-two patients completed 6-month follow-up; AMI cell infusion (n=25), AMI control (n=25), OMI cell infusion (n=16), and OMI control group (n=16). In cell infusion groups, PBSCs were mobilized by G-CSF for 3 days and delivered to infarcted myocardium via intracoronary infusion. The AMI cell infusion group showed a significant additive improvement in left ventricular ejection fraction (LVEF) and remodeling compared with controls (change of LVEF: +5.1+/-9.1% versus -0.2+/-8.6%, P<0.05; change of end-systolic volume: -5.4+/-17.0 mL versus 6.5+/-21.9 mL, P<0.05). In OMI patients, however, there was no significant change of LVEF and ventricular remodeling in spite of significant improvement of coronary flow reserve after cell infusion. G-CSF-based cell therapy did not aggravate neointimal growth with DES implantation. CONCLUSIONS: Intracoronary infusion of mobilized PBSCs with G-CSF improves LVEF and remodeling in patients with AMI but is less definite in patients with OMI. G-CSF-based stem cell therapy with DES implantation is both feasible and safe, eliminating any potential for restenosis.
- ISSN
- 1524-4539 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16820564
https://hdl.handle.net/10371/38231
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