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Expression of extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinase in the invasive trophoblasts at the human placental bed
DC Field | Value | Language |
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dc.contributor.author | Moon, K.C. | - |
dc.contributor.author | Park, J.S. | - |
dc.contributor.author | Norwitz, E.R. | - |
dc.contributor.author | Kim, D.I. | - |
dc.contributor.author | Oh, K.J. | - |
dc.contributor.author | Park, C.-W. | - |
dc.contributor.author | Jun, J.K. | - |
dc.contributor.author | Syn, H.C. | - |
dc.date.accessioned | 2009-05-27T04:08:09Z | - |
dc.date.available | 2009-05-27T04:08:09Z | - |
dc.date.issued | 2008-03-21 | - |
dc.identifier.citation | Placenta 2008;29(5):391-5 | en |
dc.identifier.issn | 0143-4004 | - |
dc.identifier.uri | https://hdl.handle.net/10371/3911 | - |
dc.description.abstract | Mitogen-activated protein kinases (MAP kinases) participate in signal transduction pathways that control embryogenesis, cell differentiation, cell proliferation and cell death. The roles of extracellular signal-regulated kinase1/2 (ERK1/2) and p38 MAP kinase in the differentiation and invasion of human trophoblasts have been studied. However, the in vivo expression and activation of ERK1/2 and p38 at the placental bed have not been elucidated. METHODS: The study group consisted of placental bed biopsy tissues obtained from the pregnancies without preeclampsia (n=24) and with preeclampsia (n=8) between 31 and 40 weeks of gestation. We evaluated the expressions and phosphorylations of ERK1/2 and p38 MAP kinase in the invasive trophoblasts in the placental bed tissues using immunohistochemistry. RESULTS: p38 and phospho-p38 MAP kinase were not detected in invasive trophoblasts in cases or controls. ERK1/2 and phospho-ERK1/2 were positive in invasive trophoblasts albeit with variable staining. Phosphorylation of ERK1/2 was significantly less frequent in invasive trophoblasts in placental bed biopsies from women with preeclampsia compared with normotensive controls. CONCLUSION: These findings suggest that preeclampsia is associated with decreased activation of ERK1/2 in invasive trophoblasts in vivo. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | ERK1/2 | en |
dc.subject | p38 MAP kinase | en |
dc.subject | Trophoblast | en |
dc.subject | Preeclampsia | en |
dc.subject | Placental bed | en |
dc.title | Expression of extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinase in the invasive trophoblasts at the human placental bed | en |
dc.type | Article | en |
dc.identifier.doi | 10.1016/j.placenta.2008.02.001 | - |
dc.citation.journaltitle | Placenta | - |
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