Publications
Detailed Information
Array-based comparative genomic hybridization and immunohistochemical studies in gliomatosis cerebri
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Hye Sook | - |
dc.contributor.author | Kim, Bomi | - |
dc.contributor.author | Park, Sung-Hye | - |
dc.date.accessioned | 2009-05-27T05:47:32Z | - |
dc.date.available | 2009-05-27T05:47:32Z | - |
dc.date.issued | 2008-08-15 | - |
dc.identifier.citation | J Neurooncol 90:259-266 | en |
dc.identifier.issn | 0167-594X (print) | - |
dc.identifier.issn | 1573-7373 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/3929 | - |
dc.description.abstract | Gliomatosis cerebri (GC) are extensively infiltrative glial tumors classified as astrocytic tumors in the current World Health Organization (WHO) classification scheme. In investigating the tumorigenesis of GC, we reviewed 28 cases of GC immunohistochemically and carried out array-based comparative genomic hybridization (CGH) in ten of those cases. In histological and immunohistochemical review, 18 cases (64%) were of astrocytic lineage, three (11%) were of oligodendroglial lineage, and seven (25%) were of uncommitted lineage. In the array-based CGH, 52 clones were frequently lost on 6p, 9p, and 9q in more than six cases, and six clones were frequently gained on 1p, 6q, 10q, and 21q in more than three cases. Some gained or lost genetic loci differed significantly between the histologically high-grade and low-grade GC (P < 0.05), but unsupervised hierarchical clustering failed to produce evidence of any clinical significance. These altered genetic foci are not known to be involved in the development of conventional glial tumors, including astrocytic tumors. In conclusion, despite the dominant astrocytic differentiation of GC histologically, novel genomic aberrations found in our GC cases were different from those of astrocytic tumors. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Gliomatosis cerebri | en |
dc.subject | Array-based comparative genomic hybridization | en |
dc.subject | Immunohistochemistry | en |
dc.title | Array-based comparative genomic hybridization and immunohistochemical studies in gliomatosis cerebri | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 민혜숙 | - |
dc.contributor.AlternativeAuthor | 김보미 | - |
dc.contributor.AlternativeAuthor | 박성혜 | - |
dc.identifier.doi | 10.1007/s11060-008-9665-7 | - |
dc.citation.journaltitle | Journal of neuro-oncology | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.