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EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number
DC Field | Value | Language |
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dc.contributor.author | Kim, M A | - |
dc.contributor.author | Lee, H S | - |
dc.contributor.author | Lee, H E | - |
dc.contributor.author | Jeon, Y K | - |
dc.contributor.author | Yang, H K | - |
dc.contributor.author | Kim, W H | - |
dc.date.accessioned | 2009-06-01T05:21:47Z | - |
dc.date.available | 2009-06-01T05:21:47Z | - |
dc.date.issued | 2008-04-10 | - |
dc.identifier.citation | Histopathology 2008; 52; 738-746 | en |
dc.identifier.issn | 0309-0167 (print) | - |
dc.identifier.issn | 1365-2559 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/4228 | - |
dc.description.abstract | AIMS: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with various genetic alterations. The aim was to investigate MYC, Bcl-2 and Bcl-6 translocations and copy number changes in adult DLBCLs to evaluate their clinicopathological features and prognostic implications. METHODS AND RESULTS: Gene status was examined using fluorescence in situ hybridization (FISH), and the results were analysed in the context of germinal centre B-cell (GCB) and non-GCB type of DLBCL based on immunohistochemistry. MYC translocation was observed in 9% (14 of 156), and an increased copy number (ICN) in 7.1% (11 of 156). MYC translocation was more common in GCB type (22%) than in non-GCB type (4.9%), and associated with advanced International Prognostic Index (IPI). MYC aberration, i.e. translocation or increased copy number (ICN), was significantly associated with shorter overall survival, especially for the GCB type. Bcl-2 translocation was rare (3.4%, five of 145), and ICN was observed in 11.7% (17 of 145), more frequently in non-GCB type (16%) than in GCB type (2.5%). Bcl-2 aberration tended to have an adverse effect on survival. In multivariate analysis, MYC ICN was an independent poor prognostic factor. CONCLUSIONS: Analyses of MYC and Bcl-2 status, i.e. translocation and ICN, in the context of DLBCL phenotype might help predict prognosis and determine therapeutic strategies. | en |
dc.description.sponsorship | This study was supported by a grant FG06-11-03 of 21C Frontier Functional Human Genome Project fromthe Ministry of Science and Technology of Korea. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.subject | epidermal growth factor receptor | en |
dc.subject | gene amplification | en |
dc.subject | stomach neoplasm | en |
dc.subject | survival analysis | en |
dc.subject | tissue array analysis | en |
dc.title | EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1365-2559.2008.03021.x | - |
dc.citation.journaltitle | Histopathology | - |
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