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Differential expression of vitreous proteins in proliferative diabetic retinopathy

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dc.contributor.authorKim, Sang Jin-
dc.contributor.authorKim, Sangmi-
dc.contributor.authorPark, Jungeun-
dc.contributor.authorLee, Hong Kyu-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorYu, Hyeong Gon-
dc.contributor.authorKim, Youngsoo-
dc.date.accessioned2010-01-24T11:41:25Z-
dc.date.available2010-01-24T11:41:25Z-
dc.date.issued2006-03-15-
dc.identifier.citationCurr Eye Res. 2006 Mar;31(3):231-40.en
dc.identifier.issn0271-3683 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16531280-
dc.identifier.urihttps://hdl.handle.net/10371/42984-
dc.description.abstractPURPOSE: To identify vitreous proteins that were differentially expressed in patients suffering from proliferative diabetic retinopathy with active neovascularization. METHODS: The vitreous samples of 15 active proliferative diabetic retinopathy patients were analyzed by two-dimensional gel electrophoresis and mass spectrometry, and the results were compared with those from age-matched patients with macular hole. RESULTS: Twenty-five protein spots were identified in the two-dimensional gel electrophoresis gels. Eight proteins (pigmented epithelium derived factor, serine protease inhibitor, apolipoprotein A-IV precursor, prostaglandin-H2 D-isomerase, a(1)-antitrypsin precursor, ankyrin repeat domain 15 protein, alpha2-HS-glycoprotein, and beta V spectrin) in the 25 spots were expressed significantly differently between the macular hole and proliferative diabetic retinopathy patients (p value < 0.05). Five proteins were upregulated in the proliferative diabetic retinopathy patients, and three were downregulated (p value < 0.05). CONCLUSIONS: We constructed vitreous protein profiles for proliferative diabetic retinopathy patients and identified eight candidate proteins believed to be involved in the pathogenesis of proliferative diabetic retinopathy.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.subjectAgeden
dc.subjectBiological Markers/metabolismen
dc.subjectDiabetic Retinopathy/complications/*metabolism/surgeryen
dc.subjectElectrophoresis, Gel, Two-Dimensionalen
dc.subjectEye Proteins/*metabolismen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMass Spectrometryen
dc.subjectMiddle Ageden
dc.subjectRetinal Neovascularization/complications/metabolism/surgeryen
dc.subjectVitrectomyen
dc.subjectVitreous Body/*metabolismen
dc.titleDifferential expression of vitreous proteins in proliferative diabetic retinopathyen
dc.typeArticleen
dc.contributor.AlternativeAuthor김상진-
dc.contributor.AlternativeAuthor김상미-
dc.contributor.AlternativeAuthor박정은-
dc.contributor.AlternativeAuthor이홍규-
dc.contributor.AlternativeAuthor박경수-
dc.contributor.AlternativeAuthor유형곤-
dc.contributor.AlternativeAuthor김영수-
dc.identifier.doi10.1080/02713680600557030-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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