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PPARgamma gene transfer sustains apoptosis, inhibits vascular smooth muscle cell proliferation, and reduces neointima formation after balloon injury in rats
DC Field | Value | Language |
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dc.contributor.author | Lim, Soo | - |
dc.contributor.author | Jin, Cheng Ji | - |
dc.contributor.author | Kim, Min | - |
dc.contributor.author | Chung, Sung Soo | - |
dc.contributor.author | Park, Ho Seon | - |
dc.contributor.author | Lee, In Kyu | - |
dc.contributor.author | Lee, Choon Taek | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.date.accessioned | 2010-01-25T12:17:57Z | - |
dc.date.available | 2010-01-25T12:17:57Z | - |
dc.date.issued | 2006-01-21 | - |
dc.identifier.citation | Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):808-13. Epub 2006 Jan 19. | en |
dc.identifier.issn | 1524-4636 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16424348 | - |
dc.identifier.uri | https://hdl.handle.net/10371/44033 | - |
dc.description.abstract | OBJECTIVE: There is still debate as to whether antiatherosclerotic effect of PPARgamma ligands is dependant on PPARgamma gene itself or some other pathway. METHODS AND RESULTS: To investigate the effect of PPARgamma gene modulation on neointima formation after balloon injury, we delivered adenoviral vectors expressing the wild-type (WT) dominant negative (DN) PPARgamma, or a control gene (beta-galactosidase [BG]) into carotid artery after balloon injury in rosiglitazone (a PPARgamma ligand)-treated (R+) (3 mg/kg/d) and nontreated (R-) rats. Two weeks after gene delivery, in both R+ and R- animals, the PPARgamma-WT gene transfer showed a significantly lower intima-media ratio (IMR) than control group. Moreover, the delivery of a PPARgamma-DN form showed the highest IMR (in R+WT, 0.51+/-0.15; R+BG, 0.89+/-0.14; R+DN, 1.20+/-0.18, P<0.05 and in R-WT, 0.91+/-0.21; R-BG, 1.44+/-0.23; R-DN, 1.74+/-0.29, P<0.05). Proliferation and migration showed same result pattern as IMR. In addition, apoptotic indices were significantly higher in the PPARgamma-WT gene transferred group than in the PPARgamma-DN group. CONCLUSIONS: In vivo transfer of the PPARgamma-WT gene was found to inhibit smooth muscle proliferation, sustain apoptosis, and reduce neointima formation after balloon injury irrespective of rosiglitazone treatment. These results indicate that PPARgamma overexpression itself has a protective role against restenosis after balloon injury. | en |
dc.language.iso | en | en |
dc.publisher | American Heart Association | en |
dc.subject | Animals | en |
dc.subject | Balloon Dilatation | en |
dc.subject | Carotid Arteries/*pathology/physiopathology | en |
dc.subject | Carotid Artery Injuries/genetics/pathology/prevention & control | en |
dc.subject | Cells, Cultured | en |
dc.subject | Gene Expression Regulation | en |
dc.subject | Gene Transfer Techniques | en |
dc.subject | Genes, fos | en |
dc.subject | Male | en |
dc.subject | PPAR gamma/*genetics | en |
dc.subject | RNA, Messenger/biosynthesis/genetics | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Tunica Intima/pathology/physiopathology | en |
dc.subject | Cell Movement | - |
dc.subject | Cell Proliferation | - |
dc.subject | Muscle, Smooth, Vascular/pathology/physiopathology | - |
dc.title | PPARgamma gene transfer sustains apoptosis, inhibits vascular smooth muscle cell proliferation, and reduces neointima formation after balloon injury in rats | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 임수 | - |
dc.contributor.AlternativeAuthor | 김민 | - |
dc.contributor.AlternativeAuthor | 정성수 | - |
dc.contributor.AlternativeAuthor | 박호선 | - |
dc.contributor.AlternativeAuthor | 이인규 | - |
dc.contributor.AlternativeAuthor | 이춘택 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.identifier.doi | 10.1161/01.ATV.0000204634.26163.a7 | - |
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