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Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia

Cited 107 time in Web of Science Cited 126 time in Scopus
Authors
Ryu, J-H; Kang, M-H; Park, K-S; Do, S-H
Issue Date
2008-02-16
Publisher
Oxford University Press
Citation
Br J Anaesth. 2008 Mar;100(3):397-403.
Keywords
AdultAnalgesia, Patient-Controlled/methodsAnalgesics/*pharmacologyAnesthesia, IntravenousAnesthetics, Intravenous/*administration & dosageDouble-Blind MethodDrug Administration ScheduleFemaleGynecologic Surgical ProceduresHumansMagnesium Sulfate/*pharmacologyMiddle AgedPain Measurement/methodsPain, Postoperative/*prevention & controlPiperidines/administration & dosagePropofol/administration & dosage
Abstract
BACKGROUND: This randomized, double-blind, prospective study was undertaken to evaluate the effects of magnesium sulphate on anaesthetic requirements and postoperative analgesia in patients undergoing total i.v. anaesthesia (TIVA). METHODS: Fifty patients who underwent gynaecological surgery were randomly divided into two groups. Before induction of anaesthesia, the magnesium group (Group M) received magnesium sulphate 50 mg kg(-1) i.v. as a bolus and then 15 mg kg(-1) h(-1) i.v. by continuous infusion. The control group (Group S) received the same amount of isotonic saline. TIVA (propofol+remifentanil) was administered under bispectral index monitoring during anaesthesia induction and maintenance. Rocuronium was administered before orotracheal intubation and during surgery when the train-of-four count was 2 or more. After operation, patient-controlled analgesia with a solution of ketorolac and morphine was used and the consumption of this solution was recorded. Pain scores at rest and upon movement were evaluated 30 min, 4, 24, and 48 h after surgery. RESULTS: Patients in Group M required less rocuronium than those in Group S [mean (SD) 0.44 (0.09) vs 0.35 (0.07) microg kg(-1) min(-1), P<0.05]. The total amounts of propofol and remifentanil administered were similar in the two groups. Postoperative pain scores, cumulative analgesic consumption, and shivering incidents were significantly lower in Group M (P<0.05). Mean arterial pressure just after intubation and during the immediate postoperative period was also significantly lower in Group M (P<0.05). CONCLUSIONS: I.v. magnesium sulphate during TIVA reduced rocuronium requirement and improved the quality of postoperative analgesia.
ISSN
1471-6771 (Electronic)
1471-6771 (Linking)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18276652

http://bja.oxfordjournals.org/cgi/reprint/100/3/397.pdf

https://hdl.handle.net/10371/45963
DOI
https://doi.org/10.1093/bja/aem407
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College of Medicine/School of Medicine (의과대학/대학원)Anesthesiology and Pain Medicine (마취통증의학전공)Journal Papers (저널논문_마취통증의학전공)
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