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Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia
Cited 115 time in
Web of Science
Cited 137 time in Scopus
- Authors
- Issue Date
- 2008-02-16
- Publisher
- Oxford University Press
- Citation
- Br J Anaesth. 2008 Mar;100(3):397-403.
- Keywords
- Adult ; Analgesia, Patient-Controlled/methods ; Analgesics/*pharmacology ; Anesthesia, Intravenous ; Anesthetics, Intravenous/*administration & dosage ; Double-Blind Method ; Drug Administration Schedule ; Female ; Gynecologic Surgical Procedures ; Humans ; Magnesium Sulfate/*pharmacology ; Middle Aged ; Pain Measurement/methods ; Pain, Postoperative/*prevention & control ; Piperidines/administration & dosage ; Propofol/administration & dosage
- Abstract
- BACKGROUND: This randomized, double-blind, prospective study was undertaken to evaluate the effects of magnesium sulphate on anaesthetic requirements and postoperative analgesia in patients undergoing total i.v. anaesthesia (TIVA). METHODS: Fifty patients who underwent gynaecological surgery were randomly divided into two groups. Before induction of anaesthesia, the magnesium group (Group M) received magnesium sulphate 50 mg kg(-1) i.v. as a bolus and then 15 mg kg(-1) h(-1) i.v. by continuous infusion. The control group (Group S) received the same amount of isotonic saline. TIVA (propofol+remifentanil) was administered under bispectral index monitoring during anaesthesia induction and maintenance. Rocuronium was administered before orotracheal intubation and during surgery when the train-of-four count was 2 or more. After operation, patient-controlled analgesia with a solution of ketorolac and morphine was used and the consumption of this solution was recorded. Pain scores at rest and upon movement were evaluated 30 min, 4, 24, and 48 h after surgery. RESULTS: Patients in Group M required less rocuronium than those in Group S [mean (SD) 0.44 (0.09) vs 0.35 (0.07) microg kg(-1) min(-1), P<0.05]. The total amounts of propofol and remifentanil administered were similar in the two groups. Postoperative pain scores, cumulative analgesic consumption, and shivering incidents were significantly lower in Group M (P<0.05). Mean arterial pressure just after intubation and during the immediate postoperative period was also significantly lower in Group M (P<0.05). CONCLUSIONS: I.v. magnesium sulphate during TIVA reduced rocuronium requirement and improved the quality of postoperative analgesia.
- ISSN
- 1471-6771 (Electronic)
1471-6771 (Linking)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18276652
http://bja.oxfordjournals.org/cgi/reprint/100/3/397.pdf
https://hdl.handle.net/10371/45963
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