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Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans

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dc.contributor.authorKim, Jin Taek-
dc.contributor.authorKim, Yeonjung-
dc.contributor.authorCho, Young Min-
dc.contributor.authorKoo, Bo Kyung-
dc.contributor.authorLee, Eun Kyung-
dc.contributor.authorShin, Hyoung Doo-
dc.contributor.authorJang, Hak Chul-
dc.contributor.authorChoi, Jung Won-
dc.contributor.authorOh, Bermseok-
dc.contributor.authorPark, Kyong Soo-
dc.date.accessioned2010-01-28T01:26:46Z-
dc.date.available2010-01-28T01:26:46Z-
dc.date.issued2008-05-10-
dc.identifier.citationClin Endocrinol (Oxf). 2009 Jan;70(1):66-74. Epub 2008 May 8.en
dc.identifier.issn1365-2265 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18466348-
dc.identifier.urihttps://hdl.handle.net/10371/45972-
dc.description.abstractOBJECTIVE: Adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2) are considered as candidate genes for type 2 diabetes because they mediate the metabolic effects of adiponectin on target tissues. We investigated whether common polymorphisms of ADIPOR1 and ADIPOR2 are associated with type 2 diabetes or its related phenotypes in Koreans. DESIGN AND PATIENTS: By sequencing of the DNA samples from 24 unrelated Korean subjects, we selected seven single nucleotide polymorphisms (SNPs) from ADIPOR1 and four SNPs from ADIPOR2 for genotyping in 757 type 2 diabetic patients and 644 nondiabetic subjects. RESULTS: None of the SNPs were associated with the risk of type 2 diabetes. However, g.-7309A>G (rs75172865) in ADIPOR1 was associated with lower insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA-IR). Thereafter, we transfected three different human cell lines with plasmids harbouring g.-7309A>G and found that this variant reduced the promoter activity of ADIPOR1. In ADIPOR2, g.-63442G (novel SNP) and g.33447T (rs1044471) were associated with smaller waist circumference. CONCLUSIONS: None of the SNPs in either ADIPOR1 or ADIPOR2 were associated with the risk of type 2 diabetes in Koreans. However, the altered activity of the ADIPOR1 promoter was associated with insulin resistance and SNPs of ADIPOR2 were associated with waist circumference.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAgeden
dc.subjectAsian Continental Ancestry Group/*geneticsen
dc.subjectCell Lineen
dc.subjectDiabetes Mellitus, Type 2/*geneticsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInsulin Resistance/geneticsen
dc.subjectKoreaen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPhenotypeen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectPromoter Regions, Geneticen
dc.subjectReceptors, Adiponectin/*geneticsen
dc.subjectRisken
dc.subjectTransfectionen
dc.subjectWaist Circumferenceen
dc.titlePolymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreansen
dc.typeArticleen
dc.contributor.AlternativeAuthor김진택-
dc.contributor.AlternativeAuthor김연정-
dc.contributor.AlternativeAuthor조영민-
dc.contributor.AlternativeAuthor구보경-
dc.contributor.AlternativeAuthor이은경-
dc.contributor.AlternativeAuthor신형두-
dc.contributor.AlternativeAuthor장학철-
dc.contributor.AlternativeAuthor최정원-
dc.contributor.AlternativeAuthor오범석-
dc.contributor.AlternativeAuthor박경수-
dc.identifier.doi10.1111/j.1365-2265.2008.03296.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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