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Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study
DC Field | Value | Language |
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dc.contributor.author | Kang, D. | - |
dc.contributor.author | Lee, K. M. | - |
dc.contributor.author | Park, S. K. | - |
dc.contributor.author | Berndt, S. I. | - |
dc.contributor.author | Peters, U. | - |
dc.contributor.author | Reding, D. | - |
dc.contributor.author | Chatterjee, N. | - |
dc.contributor.author | Welch, R. | - |
dc.contributor.author | Chanock, S. | - |
dc.contributor.author | Huang, W. Y. | - |
dc.contributor.author | Hayes, R. B. | - |
dc.date.accessioned | 2010-01-28T01:36:56Z | - |
dc.date.available | 2010-01-28T01:36:56Z | - |
dc.date.issued | 2007-07-25 | - |
dc.identifier.citation | Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1581-6. Epub 2007 Jul 23. | en |
dc.identifier.issn | 1055-9965 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17646272 | - |
dc.identifier.uri | https://hdl.handle.net/10371/45977 | - |
dc.description.abstract | Superoxide dismutase (SOD) plays a key role in the detoxification of superoxide free radicals. We evaluated the association of prostate cancer with genetic polymorphisms in SOD1 (CuZn-SOD; IVS3-251A>G), SOD2 [MnSOD; Ex2+24T>C (V16A)], and SOD3 (EC-SOD; IVS1+186C>T, Ex3-631C>G, Ex3-516C>T, and Ex3-489C>T), the three main isoforms of SOD. Prostate cancer cases (n = 1,320) from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial were frequency matched to nondiseased controls (n = 1,842) by age, race, time since initial screening, and year of blood draw. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI); stratified analysis by the level of antioxidative vitamins was also conducted. The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03). Stratification by quartiles of dietary and supplemental vitamin E intake (IU/d) showed risks of prostate cancer tended to be increased among SOD2 Ala allele carriers, except at the highest quartile of vitamin E intake (>222; P(interaction) = 0.06, Q1-Q3 versus Q4). The association between Ala allele and prostate cancer risk among those with lower intake of vitamin E ( | en |
dc.language.iso | en | - |
dc.publisher | American Association for Cancer Research | en |
dc.subject | Aged | en |
dc.subject | Alanine/genetics | en |
dc.subject | Alleles | en |
dc.subject | Antioxidants/administration & dosage | en |
dc.subject | Case-Control Studies | en |
dc.subject | Diet | en |
dc.subject | European Continental Ancestry Group/genetics | en |
dc.subject | Exons/genetics | en |
dc.subject | Genetic Variation/*genetics | en |
dc.subject | Humans | en |
dc.subject | Isoenzymes/genetics | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Genetic/*genetics | en |
dc.subject | Prostatic Neoplasms/*enzymology/genetics | en |
dc.subject | Risk Factors | en |
dc.subject | Smoking/adverse effects | en |
dc.subject | Superoxide Dismutase/*genetics | en |
dc.subject | Valine/genetics | en |
dc.subject | Vitamin E/administration & dosage | en |
dc.subject | Free Radical Scavengers | - |
dc.title | Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 박수경 | - |
dc.identifier.doi | 10.1158/1055-9965.EPI-07-0160 | - |
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