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Design issues in cross-sectional biomarkers studies: urinary biomarkers of PAH exposure and oxidative stress

Cited 14 time in Web of Science Cited 17 time in Scopus
Authors
Kang, D.; Lee, K. H.; Lee, K. M.; Kwon, H. J.; Hong, Y. C.; Cho, S. H.; Strickland, P. T.
Issue Date
2005-08-17
Citation
Mutat Res. 2005 Dec 30;592(1-2):138-46. Epub 2005 Aug 15.
Keywords
Anticarcinogenic AgentsBiological Markers/*urineCross-Sectional Studies*DNA DamageGenetic Predisposition to DiseaseHumans*Oxidative StressPolycyclic Hydrocarbons, Aromatic/adverse effects/*toxicityReproducibility of ResultsResearch DesignTea
Abstract
Cross-sectional biomarker studies can provide a snapshot of the frequency and characteristics of exposure/disease in a population at a particular point in time and, as a result, valuable insights for delineating the multi-step association between exposure and disease occurrence. Three major issues should be considered when designing biomarker studies: selection of appropriate biomarkers, the assay (laboratory validity), and the population validity of the selected biomarkers. Factors related to biomarker selection include biological relevance, specificity, sensitivity, biological half-life, stability, and so on. The assay attributes include limit of detection, reproducibility/reliability, inter-laboratory variation, specificity, time, and cost. Factors related to the population validity include the frequency or prevalence of markers, greater inter-individual variation than intra-individual variation, intra-class correlation coefficients (ICC), association with potential confounders, invasiveness of specimen collection, and subject selection. Three studies are selected to demonstrate different features of cross-sectional biomarker studies: (1) characterizing the determinants of the biomarkers (study I: urinary PAH metabolites and environmental particulate exposure), (2) relationship of multiple biomarkers of exposure and effect (study II: relationship between urinary PAH metabolites and oxidative stress), and (3) evaluating gene-environmental interaction (study III: effect of genetic polymorphisms of GSTM1 on the association of green tea consumption and urinary 1-OHPG levels in shipbuilding workers).
ISSN
0027-5107 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16102785

https://hdl.handle.net/10371/45979
DOI
https://doi.org/10.1016/j.mrfmmm.2005.06.009
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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