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Prevention of radiocontrast medium-induced nephropathy using short-term high-dose simvastatin in patients with renal insufficiency undergoing coronary angiography (PROMISS) trial--a randomized controlled study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, Sang-Ho | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Park, Jin-Shik | - |
dc.contributor.author | Kang, Hyun-Jae | - |
dc.contributor.author | Cho, Young-Seok | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Youn, Tae-Jin | - |
dc.contributor.author | Chung, Woo-Young | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Choi, Dong-Ju | - |
dc.contributor.author | Sohn, Dae-Won | - |
dc.contributor.author | Oh, Byung-Hee | - |
dc.contributor.author | Park, Young-Bae | - |
dc.contributor.author | Choi, Yun-Shik | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2010-01-28T05:34:54Z | - |
dc.date.available | 2010-01-28T05:34:54Z | - |
dc.date.issued | 2008-02-26 | - |
dc.identifier.citation | Am Heart J. 2008 Mar;155(3):499.e1-8. Epub 2008 Jan 30. | en |
dc.identifier.issn | 1097-6744 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18294484 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6W9H-4RPVJ5P-5-7&_cdi=6683&_user=168665&_orig=search&_coverDate=03%2F31%2F2008&_sk=998449996&view=c&wchp=dGLzVzz-zSkWA&md5=1ef8ffbb3147b0dbeb2a1b1238878b30&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/46132 | - |
dc.description.abstract | BACKGROUND: Contrast media cause oxidative stress, which has been suggested as one possible mechanism responsible for contrast-induced nephropathy. Statins appear to have pleiotropic effects, including antioxidant properties. We investigated to determine whether simvastatin pretreatment reduces the risk of contrast-induced nephropathy in a high-risk population of patients with renal insufficiency undergoing coronary angiography. METHODS: We conducted a prospective, randomized, double-blind, placebo-controlled, 2-center trial, involving 247 consecutive patients with chronic renal insufficiency (calculated creatinine clearance < or = 60 mL/min and/or serum creatinine > or = 1.1 mg/dL) undergoing coronary angiography. Patients were randomized to simvastatin (n = 124; 160 mg total, 40 mg orally every 12 hours starting the evening before and ending the morning after the procedure) or placebo (n = 123). All patients received pre - and postprocedure hydration. The iso-osmolar contrast agent iodixanol was used for coronary angiography in all patients. RESULTS: There was no difference between simvastatin and placebo in mean peak increase in serum creatinine measured within 48 hours after coronary angiography, the primary study end point (0.002 +/- 0.164 vs 0.017 +/- 0.230 mg/mL respectively, P = .559). The incidence of contrast-induced nephropathy, a secondary end point defined as increase of either > or = 25% or > or = 0.5 mg/dL in serum creatinine, was 2.5% in simvastatin-treated patients (3/118) and 3.4% in placebo-treated patients (4/118), a nonsignificant difference (P = 1.00). There were also no differences between the 2 groups in length of hospital stay or 1- and 6-month clinical outcomes. CONCLUSIONS: Simvastatin pretreatment for short-term at high dose do not prevent renal function deterioration after administration of contrast medium in patients with baseline renal insufficiency undergoing coronary angiography. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Administration, Oral | en |
dc.subject | Aged | en |
dc.subject | Contrast Media/*adverse effects | en |
dc.subject | Coronary Angiography/*adverse effects | en |
dc.subject | Coronary Disease/complications/*radiography | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Double-Blind Method | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Humans | en |
dc.subject | Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage | en |
dc.subject | Incidence | en |
dc.subject | Kidney Failure/chemically induced/epidemiology/*prevention & control | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Male | en |
dc.subject | Prospective Studies | en |
dc.subject | Renal Insufficiency/*complications | en |
dc.subject | Risk Factors | en |
dc.subject | Simvastatin/*administration & dosage | en |
dc.subject | Time Factors | en |
dc.subject | Treatment Outcome | en |
dc.subject | Triiodobenzoic Acids/adverse effects/diagnostic use | en |
dc.title | Prevention of radiocontrast medium-induced nephropathy using short-term high-dose simvastatin in patients with renal insufficiency undergoing coronary angiography (PROMISS) trial--a randomized controlled study | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조상호 | - |
dc.contributor.AlternativeAuthor | 구본권 | - |
dc.contributor.AlternativeAuthor | 박진식 | - |
dc.contributor.AlternativeAuthor | 강현재 | - |
dc.contributor.AlternativeAuthor | 조영석 | - |
dc.contributor.AlternativeAuthor | 김용진 | - |
dc.contributor.AlternativeAuthor | 윤태진 | - |
dc.contributor.AlternativeAuthor | 정우영 | - |
dc.contributor.AlternativeAuthor | 채인호 | - |
dc.contributor.AlternativeAuthor | 최동주 | - |
dc.contributor.AlternativeAuthor | 손대원 | - |
dc.contributor.AlternativeAuthor | 오병희 | - |
dc.contributor.AlternativeAuthor | 박영배 | - |
dc.contributor.AlternativeAuthor | 최윤식 | - |
dc.contributor.AlternativeAuthor | 김효수 | - |
dc.identifier.doi | 10.1016/j.ahj.2007.11.042 | - |
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