Browse

Upfront chemotherapy and involved-field radiotherapy results in more relapses than extended radiotherapy for intracranial germinomas: modification in radiotherapy volume might be needed

Cited 23 time in Web of Science Cited 31 time in Scopus
Authors
Eom, Keun-Yong; Kim, Il Han; Park, Charn Il; Kim, Hak Jae; Kim, Jin Ho; Kim, Kyubo; Kim, Seung Ki; Wang, Kyu-Chang; Cho, Byung-Gyu; Jung, Hee-Won; Heo, Dae Seog; Kang, Hyoung Jin; Shin, Hee Young; Ahn, Hyo Seop
Issue Date
2008-06-03
Publisher
Elsevier
Citation
Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):667-71.
Keywords
AdolescentAdultBrain Neoplasms/*mortality/*therapyChildDrug Therapy/*mortalityFemaleGerminoma/*mortality/*therapyHumansKorea/epidemiologyMaleNeoplasm Recurrence, Local/*mortality/*prevention & controlRadiotherapyRadiotherapy, Adjuvant/*mortalityRetrospective StudiesRisk Assessment/methodsRisk FactorsSurvival AnalysisSurvival RateTreatment Outcome
Abstract
PURPOSE: To retrospectively compare the outcome of upfront chemotherapy plus radiotherapy (CRT) and the outcome of the use of extended radiotherapy (RT) only for intracranial germinoma. METHODS AND MATERIALS: Of 81 patients with tissue-confirmed intracranial germinoma, 42 underwent CRT and 39 underwent RT only. For CRT, one to five cycles of upfront chemotherapy was followed by involved-field or extended-field RT, for which the dose was dependent on the M stage. For RT only, all 39 patients underwent craniospinal RT alone. The median follow-up was 68 months. RESULTS: The 5- and 10-year overall survival rate was 100% and 92.5% for RT alone and 92.9% and 92.9% for CRT, respectively. The 5-year recurrence-free survival rate was 100.0% for RT and 88.1% for CRT (p = 0.0279). No recurrences developed in patients given RT, but four relapses developed in patients who had received CRT -- three in the brain and one in the spine. Only one patient achieved complete remission from salvage treatment. The proportion of patients requiring hormonal replacement was greater for patients who received RT than for those who had received CRT (p = 0.0106). CONCLUSIONS: The results of our study have shown that the better quality of life provided by CRT was compensated for by the greater rate of relapse. The possible benefit of including the ventricles in involved-field RT after upfront chemotherapy, specifically for patients with initial negative seeding, should be addressed in a prospective study.
ISSN
0360-3016 (Print)
0360-3016 (Linking)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18514777

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T7X-4SMJMWW-5-3&_cdi=5070&_user=168665&_orig=search&_coverDate=07%2F01%2F2008&_sk=999289996&view=c&wchp=dGLbVlW-zSkzS&md5=9a9ae9c73cdd15218312b819678fef67&ie=/sdarticle.pdf

http://hdl.handle.net/10371/46138
DOI
https://doi.org/10.1016/j.ijrobp.2008.01.061
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Radiation Oncology (방사선종양학전공)Journal Papers (저널논문_방사선종양학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse