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Association of CD47 with natural killer cell-mediated cytotoxicity of head-and-neck squamous cell carcinoma lines

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dc.contributor.authorKim, Min Jung-
dc.contributor.authorLee, June-Chul-
dc.contributor.authorLee, Jae-Jung-
dc.contributor.authorKim, Soyeon-
dc.contributor.authorLee, Sang Goo-
dc.contributor.authorPark, Seok-Woo-
dc.contributor.authorSung, Myung Whun-
dc.contributor.authorHeo, Dae Seog-
dc.date.accessioned2010-01-28T08:34:38Z-
dc.date.available2010-01-28T08:34:38Z-
dc.date.issued2008-05-24-
dc.identifier.citationTumour Biol. 2008;29(1):28-34. Epub 2008 May 23.en
dc.identifier.issn1423-0380 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18497546-
dc.identifier.urihttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000132568&Ausgabe=237395&ProduktNr=224124&filename=000132568.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/46311-
dc.description.abstractOBJECTIVE: Integrin-associated protein (CD47) binds specifically to the inhibitory receptor signal-regulatory protein. This study was designed to evaluate the role of CD47 in natural killer (NK) cell-mediated cytotoxicity against cancer cells. METHODS: Head-and-neck squamous cell carcinoma (HNSCC) cell lines were analyzed for the expression of CD47 and susceptibility to NK cell-mediated killing. Cytolytic activity was assessed by (51)Cr-specific release assays and by measuring cytokine production. RESULTS: HNSCC cell lines that had high CD47 expression showed lower levels of NK cytotoxicity than those with low CD47 expression. After pre-treating cells with neutralizing major histocompatibility complex (MHC) class I or anti-CD47 antibodies, NK cell-mediated cytotoxicity against HNSCC cell lines increased. In addition, when CD47 cDNA was transfected into Caco-2 cells, NK cell-mediated cytotoxicity decreased. CONCLUSION: These findings suggest that CD47 may play an inhibitory role in NK cell-mediated cytotoxicity against cancer cells, implying a possible mechanism of immune escape in human cancer.en
dc.language.isoenen
dc.publisherKargeren
dc.subjectAntigens, CD47/genetics/*immunologyen
dc.subjectCarcinoma, Squamous Cell/*immunologyen
dc.subjectCell Line, Tumoren
dc.subjectCytotoxicity, Immunologicen
dc.subjectHead and Neck Neoplasms/*immunologyen
dc.subjectHumansen
dc.subjectKiller Cells, Natural/*immunologyen
dc.subjectTransfectionen
dc.titleAssociation of CD47 with natural killer cell-mediated cytotoxicity of head-and-neck squamous cell carcinoma linesen
dc.typeArticleen
dc.contributor.AlternativeAuthor김민정-
dc.contributor.AlternativeAuthor이준철-
dc.contributor.AlternativeAuthor이재정-
dc.contributor.AlternativeAuthor김소연-
dc.contributor.AlternativeAuthor이상구-
dc.contributor.AlternativeAuthor박석우-
dc.contributor.AlternativeAuthor성명훈-
dc.contributor.AlternativeAuthor허대석-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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