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Association of CD47 with natural killer cell-mediated cytotoxicity of head-and-neck squamous cell carcinoma lines
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Min Jung | - |
dc.contributor.author | Lee, June-Chul | - |
dc.contributor.author | Lee, Jae-Jung | - |
dc.contributor.author | Kim, Soyeon | - |
dc.contributor.author | Lee, Sang Goo | - |
dc.contributor.author | Park, Seok-Woo | - |
dc.contributor.author | Sung, Myung Whun | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2010-01-28T08:34:38Z | - |
dc.date.available | 2010-01-28T08:34:38Z | - |
dc.date.issued | 2008-05-24 | - |
dc.identifier.citation | Tumour Biol. 2008;29(1):28-34. Epub 2008 May 23. | en |
dc.identifier.issn | 1423-0380 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18497546 | - |
dc.identifier.uri | http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000132568&Ausgabe=237395&ProduktNr=224124&filename=000132568.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/46311 | - |
dc.description.abstract | OBJECTIVE: Integrin-associated protein (CD47) binds specifically to the inhibitory receptor signal-regulatory protein. This study was designed to evaluate the role of CD47 in natural killer (NK) cell-mediated cytotoxicity against cancer cells. METHODS: Head-and-neck squamous cell carcinoma (HNSCC) cell lines were analyzed for the expression of CD47 and susceptibility to NK cell-mediated killing. Cytolytic activity was assessed by (51)Cr-specific release assays and by measuring cytokine production. RESULTS: HNSCC cell lines that had high CD47 expression showed lower levels of NK cytotoxicity than those with low CD47 expression. After pre-treating cells with neutralizing major histocompatibility complex (MHC) class I or anti-CD47 antibodies, NK cell-mediated cytotoxicity against HNSCC cell lines increased. In addition, when CD47 cDNA was transfected into Caco-2 cells, NK cell-mediated cytotoxicity decreased. CONCLUSION: These findings suggest that CD47 may play an inhibitory role in NK cell-mediated cytotoxicity against cancer cells, implying a possible mechanism of immune escape in human cancer. | en |
dc.language.iso | en | en |
dc.publisher | Karger | en |
dc.subject | Antigens, CD47/genetics/*immunology | en |
dc.subject | Carcinoma, Squamous Cell/*immunology | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cytotoxicity, Immunologic | en |
dc.subject | Head and Neck Neoplasms/*immunology | en |
dc.subject | Humans | en |
dc.subject | Killer Cells, Natural/*immunology | en |
dc.subject | Transfection | en |
dc.title | Association of CD47 with natural killer cell-mediated cytotoxicity of head-and-neck squamous cell carcinoma lines | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김민정 | - |
dc.contributor.AlternativeAuthor | 이준철 | - |
dc.contributor.AlternativeAuthor | 이재정 | - |
dc.contributor.AlternativeAuthor | 김소연 | - |
dc.contributor.AlternativeAuthor | 이상구 | - |
dc.contributor.AlternativeAuthor | 박석우 | - |
dc.contributor.AlternativeAuthor | 성명훈 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
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