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Phase II evaluation of CKD-602, a camptothecin analog, administered on a 5-day schedule to patients with platinum-sensitive or -resistant ovarian cancer

Cited 17 time in Web of Science Cited 19 time in Scopus
Authors
Lee, Hyo-Pyo; Seo, Sang-Soo; Ryu, Sang-Young; Kim, Jong-Hyeok; Bang, Yung-Jue; Park, Sang-Yoon; Nam, Joo-Hyun; Kang, Soon-Beorn; Lee, Kyung-Hee; Song, Yong Sang
Issue Date
2008-06
Publisher
Elsevier
Citation
Gynecologic Oncology, Vol.109 No.3, pp.359-363
Keywords
ovarian cancerrecurrentCKD-602topoisomerase I
Abstract
Background. To evaluate the toxicity and efficacy of a newly developed topoisomerase I inhibitor, CKD-602 in second-line therapy of ovarian cancer. Methods. We enrolled 24 patients with recurrent ovarian cancer, of median age 54 years (range, 39-64). Eleven patients had measurable lesions on CT scan, and the other 13 had increased serum CA-125 levels. Eighteen patients had platinum-sensitive disease (minimum treatment free interval >= 6 months) and 6 had platinum-resistant disease (minimum treatment free interval < 6 months). CKD-602 (0.5 mg/m(2)/day) was administered intravenously for 5 days every 3 weeks. The median number of courses per patient was 6 (range, I to 12). Response was evaluated by the evaluation of the size of the mass by CT scan and CA-125 response. Results. The overall response rate was 45.0% (9/20), with 4 patients exhibiting partial responses and 5 patients exhibiting 75% CA-125 responses in 20 evaluable patients. Of the 9 responsive patients, 8 were platinum-sensitive (8/15, 53.3%) and I was platinum-resistant (115, 20.0%). An additional 5 patients showed stable disease, whereas 6 patients exhibited progressive lesions. Of 24 patients, the most common toxicity was hematological, with grades 3 or 4 neutropenia developing in all 24 patients (100%) and in 94 cycles (71.7%). Grade 3 thrombocytopenia developed in 4 patients (16.7%) and 6 cycles (4.6%). None of the patients experienced grades 3 and 4 gastrointestinal toxicities, including nausea, vomiting, and anorexia. Conclusions. The newly developed topoisomerase I inhibitor, CKD-602, showed activity against both platinum-sensitive and -resistant ovarian cancer, with acceptable toxicity. (c) 2007 Elsevier Inc. All rights reserved.
ISSN
0090-8258
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18405948

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WG6-4S80CP0-1-1&_cdi=6814&_user=168665&_orig=search&_coverDate=06%2F30%2F2008&_sk=998909996&view=c&wchp=dGLzVzz-zSkWz&md5=86a2bc37296f11b254d7bbb37aff5312&ie=/sdarticle.pdf

http://hdl.handle.net/10371/46577
DOI
https://doi.org/10.1016/j.ygyno.2007.11.023
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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