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The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats

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dc.contributor.authorChoi, Sung Hee-
dc.contributor.authorZhao, Zheng Shan-
dc.contributor.authorLee, Yong Jik-
dc.contributor.authorKim, Soo Kyung-
dc.contributor.authorKim, Dae Jung-
dc.contributor.authorAhn, Chul Woo-
dc.contributor.authorLim, Sung Kil-
dc.contributor.authorLee, Hyun Chul-
dc.contributor.authorCha, Bong Soo-
dc.date.accessioned2010-01-29T02:09:13Z-
dc.date.available2010-01-29T02:09:13Z-
dc.date.issued2007-06-01-
dc.identifier.citationDiabetes Metab Res Rev. 2007 Jul;23(5):411-8.en
dc.identifier.issn1520-7552 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17538941-
dc.identifier.urihttps://hdl.handle.net/10371/46605-
dc.description.abstractOBJECTIVE: To investigate the effects of pioglitazone and metformin treatment during pre-diabetic period for the prevention of diabetes in a rat model. METHODS: OLETF rats aged 18-weeks, were treated with pioglitazone (10 mg/kg/day) and metformin (300 mg/kg/day) for 10 weeks from their pre-diabetic period. We measured weight, lipid profiles, fat distribution, glucose tolerance, and pancreatic insulin content. RESULTS: Prominent weight gain (mostly subcutaneous fat area) was observed in the pioglitazone-treated OLETF (O-P) rats versus significant weight loss was observed in the metformin-treated OLETF (O-M) rats. Pioglitazone reversed the serum triglyceride (TG) and FFAs levels to normal (TG 0.46 +/- 0.04 vs 0.88 +/- 0.05 mmol/l in LETO). At the age of 28 weeks, the O-P rats showed completely normal glucose tolerance, and the glucose disposal rate (GDR) was markedly improved (25.6 +/- 0.4 vs 20.6 +/- 0.5 mg/min/kg in O-C, p < 0.05). The O-M rats also showed an improved fasting glucose and GDR level, but not as much as those with O-P rats. The pancreas insulin contents were much improved in the O-P rats (22.9 +/- 1.2 vs 18.8 +/- 1.3 nmol/pancreas in O-M rats, p < 0.05) with histological improvement. CONCLUSION: The pre-diabetic treatment with pioglitazone, despite significant weight gain, completely prevents to develop diabetes and enhances beta cell function with preservation of islet cell changes. Metformin treatment was also effective, but mainly by ameliorating the insulin resistance with marked reduction in body weight. The reversal of dyslipidaemia and the fat redistribution might contribute to the greater improvement of pioglitazone treatment compared to metformin in OLETF rats.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAnimalsen
dc.subjectDiabetes Mellitus, Type 2/*prevention & controlen
dc.subjectDisease Models, Animalen
dc.subjectHypoglycemic Agents/therapeutic useen
dc.subjectMetformin/therapeutic useen
dc.subjectPrediabetic State/drug therapyen
dc.subjectRatsen
dc.subjectRats, Inbred OLETFen
dc.subjectThiazolidinediones/therapeutic useen
dc.subjectWeight Gain/drug effectsen
dc.subjectWeight Loss/drug effectsen
dc.titleThe different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF ratsen
dc.typeArticleen
dc.contributor.AlternativeAuthor최성희-
dc.contributor.AlternativeAuthor이용직-
dc.contributor.AlternativeAuthor김수경-
dc.contributor.AlternativeAuthor김대중-
dc.contributor.AlternativeAuthor안철우-
dc.contributor.AlternativeAuthor임성길-
dc.contributor.AlternativeAuthor이현철-
dc.contributor.AlternativeAuthor차봉수-
dc.identifier.doi10.1002/dmrr.756-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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