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Visceral fatness and insulin sensitivity in women with a previous history of gestational diabetes mellitus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Soo | - |
dc.contributor.author | Choi, Sung Hee | - |
dc.contributor.author | Park, Young Joo | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Jang, Hak C | - |
dc.contributor.author | Cho, Nam H | - |
dc.contributor.author | Metzger, Boyd E | - |
dc.date.accessioned | 2010-01-29T04:42:19Z | - |
dc.date.available | 2010-01-29T04:42:19Z | - |
dc.date.issued | 2007-01-30 | - |
dc.identifier.citation | Diabetes Care. 2007 Feb;30(2):348-53. | en |
dc.identifier.issn | 0149-5992 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17259506 | - |
dc.identifier.uri | https://hdl.handle.net/10371/46671 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to investigate the insulin sensitivity and visceral fatness in women with previous gestational diabetes mellitus (GDM), who are prone to develop type 2 diabetes. RESEARCH DESIGN AND METHODS: A 75-g oral glucose tolerance test (OGTT) performed 1 year postpartum identified 21 GAD(-) women with previous GDM and impaired glucose tolerance (GDM-IGT). Sixty age- and BMI-matched women with normal glucose tolerance (GDM-NGT) were selected by 1:3 matching to the GDM-IGT group. Another 18 women with normal glucose metabolism during a previous pregnancy and no family history of diabetes were recruited as the normal control group. Age and BMI matching was performed using a range of +/-1.0 years and +/-1.0 kg/m(2), respectively. Total body fat was measured by tetrapolar bioelectrical impedance, and visceral fat was determined using a single cut of a computed tomography scan. Insulin sensitivity was determined by the minimal model technique using the frequently sampled intravenous glucose tolerance test. RESULTS: One year postpartum, visceral fat was greater in the GDM-IGT group than in the age- and BMI-matched GDM-NGT or normal control groups. The insulin sensitivity index was lower in the GDM-IGT group than in the GDM-NGT or normal control groups. beta-Cell function, as measured by the acute insulin response to glucose, was also lower in GDM-IGT. CONCLUSIONS: High body fat content, especially visceral fat content, and a low insulin response to glucose seem to contribute simultaneously to the development of impaired glucose metabolism in Korean women with previous GDM. | en |
dc.language.iso | en | en |
dc.publisher | American Diabetes Association | en |
dc.subject | Adipose Tissue/*anatomy & histology | en |
dc.subject | Adult | en |
dc.subject | Blood Glucose/drug effects/metabolism | en |
dc.subject | Body Mass Index | en |
dc.subject | Diabetes, Gestational/*physiopathology | en |
dc.subject | Female | en |
dc.subject | Glucose Intolerance/*epidemiology | en |
dc.subject | Glucose Tolerance Test | en |
dc.subject | Hemoglobin A, Glycosylated/analysis | en |
dc.subject | Humans | en |
dc.subject | Insulin/blood/pharmacology | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Pregnancy | en |
dc.subject | Risk Factors | en |
dc.subject | Viscera/anatomy & histology | en |
dc.subject | Body Composition | - |
dc.title | Visceral fatness and insulin sensitivity in women with a previous history of gestational diabetes mellitus | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 임수 | - |
dc.contributor.AlternativeAuthor | 최성희 | - |
dc.contributor.AlternativeAuthor | 박영주 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.identifier.doi | 10.2337/dc06-1405 | - |
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