S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
구강 편평세포암종에서 조직학적 침습양상과 분화도에 따른 Matrix Metalloproteinase-2와 -9의 발현
Expression of Matrix Metalloproteinase-2 and -9 in Oral Squamous Cell Carcinomas in Relation to the Histologic Invasiveness and Cellular Differentiation
- Issue Date
- 대한병리학회지 146('99.4) pp.243-250
- A poor prognosis of oral squamous cell carcinoma (SCC) is partly due to the invasiveness and metastasis of the tumor. A key element in tumor invasion and metastasis in the degradation of extracellular matrix is matrix metalloproteinases (MMPs). This study was performed to determine the expression of MMP-2 and MMP-9 of oral SCCs with regard to the histologic invasiveness and differentiation in 5 normal oral mucosa and 36 oral SCCs. The histologic invasiveness of oral SCCs were classified into 4 grades. The differentiation of oral SCCs was divided into 3 grades. The streptavidin-biotin immunohisto-chemical staining, using MMP-2 and MMP-9 monoclonal antibodies, was performed to determine the expression of MMP-2 and MMP-9. The expression of MMP-2 was positive in 6 of 17 oral SCCs with weak invasiveness and was positive in 7 of 19 oral SCCs with strong invasiveness. The MMP-2 expression did not increase significantly with respect to the invasiveness of oral SCCs (p>0.05). The expression of MMP-9 was strongly positive in 6 out 17 SCCs with weak invasiveness and was strongly positive in 14 of 19 SCCs with strong invasiveness.
The MMP-9 expression increased significantly with respect to the invasiveness of oral SCCs; the stronger the expression, the stronger the invasiveness (p<0.05). The expression of MMP-9 was in 57.9% of well differentiated SCCs, 57.1% of moderately differentiated ones, and 33.3% of poorly differentiation SCCs. The expression of MMP-2 and MMP-9 did not increase significantly with respect to the histologic ifferentiation. We conclude that with respect to the invasiveness, the MMP-9 did not increase significantly in oral SCCs but the MMP-2 expression does not; and that with respect to the histologic differentiation, their expression do not increase significantly. These
results suggest that MMP-9 can be used as a tool to evaluate the invasiveness of oral SCCs.
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