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Eugenol inhibits K+ currents in trigeminal ganglion neurons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, H. Y | - |
dc.contributor.author | Park, C. K | - |
dc.contributor.author | Jung, S. J | - |
dc.contributor.author | Choi, S. Y | - |
dc.contributor.author | Lee, S. J | - |
dc.contributor.author | Park, K | - |
dc.contributor.author | Kim, J. S | - |
dc.contributor.author | Oh, S. B | - |
dc.date.accessioned | 2010-02-01T06:01:42Z | - |
dc.date.available | 2010-02-01T06:01:42Z | - |
dc.date.issued | 2007-09 | - |
dc.identifier.citation | JOURNAL OF DENTAL RESEARCH 86:898-902. | en |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://hdl.handle.net/10371/47231 | - |
dc.description.abstract | Eugenol, a natural capsaicin congener, is widely used in dentistry. Eugenol inhibits voltage-activated Na+ and Ca^sup 2+^ channels in a transient receptor potential vanilloid 1 (TRPV1)-independent manner. We hypothesized that eugenol also inhibits voltage-gated K+ currents, and investigated this in rat trigeminal ganglion neurons and in a heterologous system using whole-cell patch clamping. Eugenol inhibited voltage-gated K+ currents, and the inhibitory effects of eugenol were observed in both capsaicin-sensitive and capsaicin-insensitive neurons. Pre-treatment with capsazepine, a well-known antagonist of TRPV1, failed to block the inhibitory effects of eugenol on K+ currents, suggesting no involvement of TRPV1. Eugenol inhibited human Kv1.5 currents stably expressed in Ltk^sup -^ cells, where TRPV1 is not endogenously expressed. We conclude that eugenol inhibits voltage-gated K+ currents in a TRPV1-independent manner. The inhibition of voltage-gated K+ currents is likely to contribute to the irritable action of eugenol. Abbreviations: human Kv1.5 channel, hKv1.5; transient receptor potential vanilloid 1, TRPV1. | en |
dc.language.iso | en | en |
dc.publisher | American and International Associations for Dental | en |
dc.subject | eugenol | en |
dc.subject | trigeminal ganglion neurons | en |
dc.subject | voltage-gated K+ currents | en |
dc.subject | Kv1.5 | en |
dc.title | Eugenol inhibits K+ currents in trigeminal ganglion neurons | en |
dc.type | Article | en |
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