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effects of conditionde media from periodontal ligament cells and gingival fibroblasts on the proliferation and differentiation in osteoblastic clond mc3t3-e1cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Gwan-shik | - |
dc.contributor.author | Moon, Ki-ho | - |
dc.contributor.author | Lee, In-seok | - |
dc.date.accessioned | 2010-02-01T06:04:11Z | - |
dc.date.available | 2010-02-01T06:04:11Z | - |
dc.date.issued | 1995-06 | - |
dc.identifier.citation | Journal of Oral Biology.19: 41-46, 1995. | en |
dc.identifier.issn | 1225-6390 | - |
dc.identifier.uri | https://hdl.handle.net/10371/47278 | - |
dc.description.abstract | To determine whether the human periodintal ligament cell-conditioned medium (PDL-CM) and the human alngival fibroblast-conditioneed medium (GF-CM) affect the proligeration and differentiation of osteoblastic cline MC3T3-E1 cells, the effects of both conditioned media on [^(3)H]thymidine incorporation into DNA and alkalin phosphatase (ALP) activity in cline MC3T3-E1 cells were examined. Both PDL-Cm and GF-Cm increased [^(3)H]thymidine incroporation into DNA whereas decreased ALP activity in dose-dependent manner. Especially, their inhibitory effect on ALO activity was proportional to the seeding density of MC3T3-E1 cells and concentration of CM. These findings indicated that PDL and GF produce and release certain soluble factor(s) that stimulate cell proliferation and inhibit differentialtion in MV3T3-E1 cells and suggest that PDL and GF may play a role in the regulation of bone cell function in vivo as well. | en |
dc.language.iso | en | en |
dc.publisher | The Korean Academy of Oral Biology | en |
dc.subject | conditioned medium | en |
dc.subject | periodontal ligament cells | en |
dc.subject | gingival fibroblasts | en |
dc.subject | MC3T3-Fl | en |
dc.subject | cell proliferation | en |
dc.subject | alkaline | en |
dc.title | effects of conditionde media from periodontal ligament cells and gingival fibroblasts on the proliferation and differentiation in osteoblastic clond mc3t3-e1cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김관식 | - |
dc.contributor.AlternativeAuthor | 문기호 | - |
dc.contributor.AlternativeAuthor | 이인석 | - |
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