S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Natural Antibiotics: Antimicrobial Peptides
- 김연숙; 김정재; 최영님
- Issue Date
- 대한치과의사협회지 2003;41(2):116-125
- Antimicrobial peptides are natural antibiotics evolved by many plants, invertebrate, and vertebrate to defend against the microbial infection. Antimicrobial peptides show a broad-spectrum antimicrobial activity with little opportunity for the development of resistance since they target microbial membranes that distinguish microbes from eukaryotic cells. The oral cavity is constantly exposed to microbial challenges and antimicrobial peptides play an important role in maintaining the oral health. With the increase of resistant micro-organisms to conventional antibiotics, antimicrobial peptides are attracting interests as novel antibiotics. In this review, the characteristics of antimicrobial peptides including the classification, mechanism of action, resistance, and expression in the oral cavity have been discussed in the prospect of application to oral diseases.