다양한 형태의 다공질 calcium metaphosphate의 생분해성에 관한 장기적 연구

Abstract

The purpose of this study is to evaluate the biocompatibility and the biorsorbability of several types of calcium polyphosphate made through change of manufacturing process for 12 month. To solve limitation of calcium phosphate, we developed a new ceramic, Calcium Polyphosphate(CPP), and report the biologic response to CPP in extraction sites of beagle dog. Porous CPP blocks were prepared by condensation of anhydrous $Ca(H_2PO_4)_2$ to form non-crystalline Ca(PO3)2 and then milled to produce CPP powder. CPP powder, CPP block, and CPP granules added with Na2O were implanted in extraction sockets and histologic observation were performed at 12 months later. Like 3 months results, histologic observation at 12 months revealed that CPP matrix were mingled with and directly apposed to new bone without any adverse tissue reaction, CPP powder show direct bony contact, but new bone formation and fibrous tissue encapsulation showed in CPP block. 10% Na2O CPP granules show more inflammatory cells infiltration around graft materials compared at 3 month, but 15% Na2O CPP granules show less. This result revealed that regardless of addition of Na2O, CPP had a high affinity for bone and had been resorbed slowly. From this results, it was suggested that CPP is promising ceramic as a bone substitute and addition of Na2O help biodegradation but optimal concentration of Na2O and other additive component to increase degradation rate should be determined in further study.