구강 캔디다 보유 및 캔디다 수와 타액내 ABH 혈액형 항원 분비와의 관계

Abstract

The aims of the present study were to determine the oral Candida carriage rate using whole saliva culture(WSC) and concentrated oral rinse culture(CRC) in healthy subjects, to compare the sensitivities of these sampling techniques, and to investigate the relationship between the oral Candida carriage and counts and ABO blood groups or the secretion status of ABH blood group antigens. Unstimulated whole saliva and concentrated oral rinse samples were obtained from 90 healthy subjects. These samples were plated on Sabourauds dextrose agar media for determination of the oral Candida carriage and counts. Fresh whole saliva samples were subjected to SDS-PAGE and immunoblotting to determine the secretion status of the blood group antigens. The oral Candida carriage rate was 45.6%. The sensitivity of the CRC was 85.4% and that of WSC was 78.0%. There was no significant relationship between the Candida carriage and counts and the blood group or secretion status of ASH blood group antigens in saliva. However, the oral Candida carriage rate was higher in the subjects with blood type O and ABH antigen non-secretors. There was no significance correlation between the flow rate of unstimulated whole saliva and oral Candida counts. Further studies including larger number of subjects and considering other blood group antigens and local factors are needed to investigate what determines oral Candida carriage in healthy subjects.