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성견 치주인대세포의 줄기세포 특성 연구

DC Field Value Language
dc.contributor.author김경화-
dc.contributor.author김수환-
dc.contributor.author설양조-
dc.contributor.author이용무-
dc.date.accessioned2010-02-01T06:15:01Z-
dc.date.available2010-02-01T06:15:01Z-
dc.date.issued2007-
dc.identifier.citation대한치주과학회지 2007;37:479-488en
dc.identifier.issn0250-3352-
dc.identifier.urihttp://uci.or.kr/G100:I100-KOI(KISTI1.1003/JNL.JAKO200721452725207)-
dc.identifier.urihttps://hdl.handle.net/10371/47496-
dc.description.abstractIn spite of the attention given to the study of mesenchymal stem cells derived periodontal ligament (PDL), there is a lack of information about canine PDL cells. In this study, we characterized canine PDL cells to clarify their stem cell properties, including self renewal, proliferate rate, stem cell markers and multipotency. PDL cells were obtained from extracted premolars of canines, following a colony forming assay and proliferation rate of sub-confluent cultures of cells for self-renewal, immunostaining for STRO-1 and CD146/MUC18 and a differentiation assay for multipotency. Canine PDL cells formed single-cells colonies and 25% of the PDL cells displayed positive staining for BrdU. The cells expressed the mesenchymal stem-cell markers, STRO-1 and CD146/MUC18. Under defined culture conditions, the cells differentiated into osteoblasts and adipocytes, but the cells didn't differentiated into chondrocytes. The findings of this study indicated that the canine PDL cells possess crucial stem cells properties, such as self-renewal and multipotency, and express the mesenchymal stem cell markers on their surface. The isolation and characterization of canine PDL cells makes it feasible to pursue preclinical models of periodontal regeneration in canine.en
dc.description.sponsorship이 논문은 2006년도 정부(과학기술부)의 재원으로, 한국과학재단의 지원을 받아 수행된 연구입니다.en
dc.language.isokoen
dc.publisher대한치주과학회en
dc.subjectcanineen
dc.subjectmesenchymal stem cellsen
dc.subjectPDLen
dc.subjectmultipotencyen
dc.subjectSTRO-1en
dc.subjectCDl46/MUC18en
dc.title성견 치주인대세포의 줄기세포 특성 연구en
dc.typeArticleen
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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