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구강 편평태선 환자에서 steroid와 cyclosporine의 국소 도포 효과
THE EFFECT OF TOPICAL APPLICATION WITH STEROID AND CYCLOSPORINE ON ORAL LICHEN PLANUS PATIENTS

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Authors
홍순민; 박성진; 박지현; 윤필영; 명훈; 고홍섭; 정성창; 이종호; 김명진
Issue Date
2004
Publisher
대한구강악안면외과학회
Citation
대한구강악안면외과학회지 30(3):203-210
Keywords
Oral lichen planusSteroidCyclosporineImmunosupressant
Abstract
The purpose of this study was comparing the effectiveness in the topical applications of cyclosporine with that of steroid, the conventional and standard drug in the treatment of oral lichen planus. 21 patients with oral lichen planus were treated with cyclosporine (n=11) or steroid (n=10) by random allocations. They were recalled 2 weeks, 4 weeks, and 8 weeks after initial treatments. In each recall, the lesion size, clinical symptoms like pain or burning sensation, and side effects were evaluated. The differences of these measurements were compared and the effects of each drug were checked. In reticulation types, steroid showed higher effectivity than cyclosporine and this difference was significant statistically. But in erythema type lesions, either drug showed no significant recovery, statistically. However, the effect of cyclosporine was thought to be more effective. The pain of the lesions was significantly decreased by cyclosporine but not by steroid. The decrease of burning sensation was more dependant upon steroid than cyclosporine, but no statistical relationship could be found. There were no clinical side effects. There was limitation to draw in conclusion due to small pool of this study group. But with the results, this suggestion could be proposed that either drug might be superior to another in effectivity in a specific lesion type or patient symptom, so selection and usage of one drug in a specific case could be better than universal application of one drug in all cases.
ISSN
1225-1585
Language
Korean
URI
http://hdl.handle.net/10371/47591
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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