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악관절환자에서 Synovial fluid에 대한 단백질체 분석에 관한 연구
THE ANALYSIS OF SYNOVIAL FLUID BY PROTEOMICS FROM TMD

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Authors
변은선; 김태우; 김상균; 박태일; 박준우; 윤필영; 김윤구; 채창훈
Issue Date
2008
Publisher
대한구강악안면외과학회
Citation
대한구강악안면외과학회지 34(2):113-118
Keywords
Temporomandibular joint disorder (TMDProteomics; Synoviolin
Abstract
Temporomandibular joint disorder (TMD) can induce severe pain but, its pathogenic mechanisms remain poorly understood. In this study, we analyzed proteomes of human synovial fluid in the superior joint space in the patients with TMD, which is obtained during the treatment arthrocentesis. We've got this result that one of the spots was consistently down-regulated in synovial fluid of patients with TMD from analysis of protein pattern. Its molecular weight was estimated to be 33 kDa. Synoviolin was identified in our proteomics analysis of LC/MS/MS. This protein was recently reported as one of the proteins that might affect rheumatoid arthritis (RA). Synoviolin that might be associated with RA was detected in synovial fluid of patients with TMD. We can conclude that synoviolin might be involved not only in the pathogenesis of RA but also in TMD. In result, synoviolin might be involved in the pathogenesis of TMD and can be candidates as new therapeutic targets of TMD or early detection biomarkers.
ISSN
1225-1585
Language
Korean
URI
https://hdl.handle.net/10371/47925
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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