S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 27 No.1 (1986)
Effect of Prostaglandin E2 on Reflex Adrenal Catecholamine Secretion
부신의 반사성 Catecholamine 분비에 대한 Prostaglandin E2의 영향
- Oh, Seung Keun; Harrison, Timothy S.
- Issue Date
- Seoul J Med, Vol.27 No.1, pp. 59-64
- Prostaglandin E2 was administered peripherally and centrally to experimental
dogs in order to demonstrate the effect of prostaglandin E2 on reflex adrenal secretion of
catecholamines following hemorrhage in acutely anephric conditions.
Diminished adrenal catecholamine secretion in anephric dogs was restored by peripheral
infusion of prostaglandin E2 dose-dependently. Almost an identical response of adrenal secretion
was observed by the peripheral and central infusions of prostaglandin E2, suggesting its
effect is not selectively mediated by the central nervous system in contrast to angiotensin II.
The action of prostaglandin E2 on the adrenal medulla in relation to the renin-angiotensin
system appears to be systemic.