S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 27 No.2 (1986)
Histopathology of Small Intestines of Rats and Mice Experimentally Infected with Pygidiopsis summa
소장(小腸)의 조직병리학적 연구
- Seo, Byong-Seol; Cheong, Seung Kie; Chai, Jong-Yil; Lee, Soon-Hyung; Lee, Jung Bin
- Issue Date
- Seoul J Med, Vol.27 No.2, pp. 125-134
- A histopathological study was performed on the intestine of rats and mice
experimentally infected with Pygidiopsis summa. Total 16 rats and 12 mice were infected
orally each with 1,000 metacercariae collected from the mullets. After 3 days to 5 weeks their
small intestines were studied.
While controls showed only a slight degree of non-specific inflammation in the villous
stroma, those infected with P. summa revealed diffuse and remarkable mucosal changes
during the early stage up to 2-3 weeks of infection. The mucosal pathology was chiefly villous
atrophy (thickening, blunting of tips and fusion) with severe stromal inflammation, accompanied
by crypt hyperplasia. No invasion of worms into the submucosa was recognized.
Later than 3 weeks, however, the diseased mucosa began to restore their normal features.
At 4-5 weeks mucosal layer became normal, except for slight stromal inflammation and/or