Vascular Changes in Relation with Tumor Regression Induced by Combined Oral Administration of Heparin and Hydrocortisone

Abstract

The oral administration of heparin and hydrocortisone inhibited the tumor growth and induced the regression of the solid myeloma implanted on the back of BalbC mice. The inhibition of tumor growth was dependent on the regimen, which was suggested by the reactivation of tumor growth with interruption of the theraphy. The histologic analysis of those tumors revealed intravascular deposition of fibrillary eosinophilic substances and necrosis of tumors as well as the thickening of the vascular wall. The present experiment confirmed the tumor inhibition effect of Folkman's heparin and hydrocortisone treatment and found that the regimen could induce the vascular change in addition to the proposed angiogenesis inhibition.