S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 30 No.1 (1989)
The Proton Nuclear Magnetic Resonance Spectral Analysis of Human Blood Plasma Lipoprotein
혈장 지단백질에 대한 핵자기 공명 분광분석
- Song, In-Chan; Kang, Sa-Ouk; Kim, Noe-Kyeong; Im, Jung-Gi; Min, Byoung-Goo
- Issue Date
- Seoul J Med, Vol.30 No.1, pp. 31-36
- 300 MHZ proton NMR spectra of human blood plasma were analyzed by
deconvolution of spectrum, and we compared its results with Fossel's test in normal (15
cases), liver cancer (14 cases), and other cncer (14 cases) groups. This analysis had enabled
us to obtain dynamic characteristics of each individual lipoprotein.
As a result of deconvolution method, the VLDL and chylomicron intensity level were
found to be elevated in the patients with liver cancer. Moment ratio values of CH2 resonance
in the raw spectrum were found to be higher than the normal group for patients with
malignant tumors other than liver cancer. These differences between the three groups could
not be found in the conventional Fossel's test.
We could simulate plasma spectra by addition of spectra of individual liporoteins through
deconvolution method. Further clinical trials in larger populations and additional biochemical
method may shed new light on many of clinical and biochemical interests for knowing
charateristics about lipoprotein not separated from blood and the background of Fossel test.