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Enhancement of Antithrombogenicity by Urokinase Immobilization on the Gelatin-Adsorbed Polyurethane Surface : 항혈전성 향상을 위한 폴리우레탄표면에 대한 젤라틴과 유로키나제의 고정화
DC Field | Value | Language |
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dc.contributor.author | Ryu, Gyu-Ha | - |
dc.contributor.author | Park, Seon-Yang | - |
dc.contributor.author | Cho, Han-Ik | - |
dc.contributor.author | Min, Byoung-Goo | - |
dc.date.accessioned | 2009-07-14T14:10:13Z | - |
dc.date.available | 2009-07-14T14:10:13Z | - |
dc.date.issued | 1989-03 | - |
dc.identifier.citation | Seoul J Med, Vol.30 No.1, pp. 37-46 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/5533 | - |
dc.description.abstract | The porous polyurethane (PU) sheet was impregnated with 5% (w/v) gelatin
solution and the fibrinolytic enzyme to promote the antithrombogenicity of artificial ventricle's surface. Urokinase was immobilized on the gelatin-treated surface with 0.45% (w/v) buffered glutaraldehyde solution (pH 7.4). The coagulation time was delayed to 1.2 times in the gelatin-urokinase co-immobilized surface than the nonporous PU control by APTT measurement. By urokinase immobilization, the maximal activities of the enzyme were elongated (from 2 hour to 4 hour). In vitro study shows that the antithrombogenicity was improved after gelatin adsorption and urokinase immobilization on the polyurethane. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Urokinase immobilization | - |
dc.subject | Gelatin | - |
dc.subject | Antithrombogenicity | - |
dc.title | Enhancement of Antithrombogenicity by Urokinase Immobilization on the Gelatin-Adsorbed Polyurethane Surface | - |
dc.title.alternative | 항혈전성 향상을 위한 폴리우레탄표면에 대한 젤라틴과 유로키나제의 고정화 | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 류규하 | - |
dc.contributor.AlternativeAuthor | 박선양 | - |
dc.contributor.AlternativeAuthor | 조한익 | - |
dc.contributor.AlternativeAuthor | 민병구 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 46 | - |
dc.citation.number | 1 | - |
dc.citation.pages | 37-46 | - |
dc.citation.startpage | 37 | - |
dc.citation.volume | 30 | - |
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