Publications
Detailed Information
Bayesian Feedback Method for Optimum Phenytoin Dosing : Phenytoin 용량적정화를 위한 Bayesian Feedback법
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Issue Date
- 1989-06
- Citation
- Seoul J Med, Vol.30 No.2, pp. 105-111
- Keywords
- Phenytoin ; Dosage prediction ; Bayesian method ; Ludden method ; Richens & Dunlop method
- Abstract
- The accuracy of Bayesian feedback method for predicting phenytoin dosage
was assessed and compared to conventional predictive methods such as the Richens &
Dunlop method and Ludden method from 57 patients who took phenytoin for the treatment
of grandmal epilepsy, For the comparison of absolute predictability of each method, correlation
coefficient between predicted and actual dosage, mean error (ME) and root mean
squared error (RMSE) were calculated. For a single data pair, the Bayesian method showed a
higher correlation coefficient (0.915) and' less ME & RMSE values( -2.0'1"0 & 8.8'X)) than the
Richens & Dunlop methood, and there was a staitistically significant difference between these
two methods (p < 0,05). For multiple dat pairs, the Bayesian method also showed a higher
correlation coefficient (0,93) and less ME & RMSE values (0.69% & 7.2<1'0), though there was
no significant difference. It is suggested that the Bayesian method has better predictability
and can be used conveniently even with single Cpss-dosc data pair for optimum phenytoin
dosage prediction.
- ISSN
- 0582-6802
- Language
- English
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.