S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 30 No.2 (1989)
Cardiovascular Effects of Water-soluble Benzodiazepine as an Anesthesia Induction Agent
수용성 Benzodiazepine 약제의 마취유도중 심폐혈관에 미치는 영향
- Kim, Chong Sung; Kim, Kwang Woo
- Issue Date
- Seoul J Med, Vol.30 No.2, pp. 127-132
- The new benzodiazepine, midazolam, that is water-soluble, shorter-acting,
more potent, and less irritating to veins than diazepam, has been suggested use for induction
of anesthesia. The induction tme (from the end of injection to spontaneous closing of eyes
and to the disappearance of eyelash reflex), cardiovascular effects (mean arterial pressure;
MAP, heart rate; HR, cardiac output; CO), and the effect on arterial oxygen saturation (Sa02)
of an induction-sized dose (0.2 mg/kg) of midazolam in ASA class I or II surgical patients (N
= 10) premedicated with glycoppyrolate were compared with those in the similar group of
patients (N = 10) receiving thiopental (5 mg/kg). The induction time in midazolam group
was significantly slower than in thiopental group. In both groups MAP decreased during
induction but increased after intubation significantly. HR significantly increased at early induction
period in thiopental group, and significantly increased after intubation in both groups.
CO significantly decreased in thiopental group but did not change in midazolam group. In
both groups Sa O2 did not change during induction but significantly increased after intubation.
Although induction time was slow, midazolam, from the cardiovascular point of view,
appears to offer some advantages over thiopental and, clinically, is at least as good as
thiopental as an anesthesia induction agent in healthy surgical patients.