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The Effect of Cyclosporine and Dexamethasone on Suppression of Medial Thickening after Arterial Injury in Rats

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Authors
Lee, Tae Seung; Kim, Sang Joon
Issue Date
1993-12
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.34 No.4, pp. 265-273
Keywords
Myointimal hyperplasiaImmunosuppressive agentsCyclosporineDexamethasone
Abstract
Vascular proliferative lesion is one of the most important causes of stenosis
and late thrombosis in arterial reconstructions. We studied the effect of
cyclosporine and dexamethasone on decreasing the hyperplastic response after experimental
arterial injury in rats. Ninety female rats were assigned to one of four groups,
each receiving daily subcutaneous injections of either (1) saline (control), or (2)
cyclosporine(CYA) 5mg/Kg/D, or (3) dexamethasone (DEXA) O. 1 mg/Kg/D, or (4)
CYA 5mg/kg/D and DEXA O. Img/kg/D. Injections were started 1 day before the
intimal injury and continued daily for 6 weeks. Arterial injury was created in 90 rats by
rotating a Imm coronary dilator in the right common iliac artery. The vessels were
harvested 1,4,6 weeks after injury and the thickness of the tunica media was measured.
In the control group the injured iliac artery had significant medial thickening when
compared to the noninjured (P(O. 0001) 1 week after injury. Injured arteries treated
with CYA or DEXA or CYA and DEXA showed significantly less medial thickening
when compared to that of control (P(O. 001) but no significant difference was noted
among drug treated groups for 1 and 4 weeks of treatment. At 6 weeks, however, medial
thickness in the CYA and DEXA group was significantly less than that of the CYA
or DEXA group(P( O. 05).
These data suggest that CYA and DEXA are effective in suppressing the
hyperplatic myointimal reaction to an intimal injury. In addition, these data also provide
the evidence that immunological mechanisms may modulate vascular proliferative
lesions.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/5567
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.4 (1993)
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