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Growth Hormone Response to Clonidine In Treatment-Resistant Schizophrenia

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Authors
Ha, Kyoo-Seob; Kim, Yong-Sik
Issue Date
1993-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.34 No.3, pp. 215-222
Keywords
Treatment-resistant schizophreniaGrowth hormoneClonidineBlunted responseWithdrawal-retardation
Abstract
To examine whether there are abnormalities in growth hormone
(GH) response to clonidine among treatment-resistant schizophrenics, the authors
investigated the GH response to clonidine in 20 treatment-resistant male
schizophrenics and in 16 normal controls. There was no statistically significant
difference in the mean maximal L1GH, the level of GH at any observed time point,
the mean duration required for the peak of GH response and the percentage of
the blunted GH response between the treatment-resistant schizophrenics regardless
of haloperidol administration and normal controls except for much wider
variations of maximal L1GH values in the treatment-resistant schizophrenics. In
the relationship between the clinical variables and GH responsiveness, under the
haloperidol medication no clinical variables were related with maximal L1GH, but
2 weeks after discontinuation of haloperidol, withdrawal-retardation subscore of
BPRS was negatively correlated with maximal L1GH. Similarly, in a comparison
between the GH responsive and the blunted group, only at haloperidol withdrawal
state, did the blunted group show a higher withdrawal-retardation subscore of
BPRS.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/5574
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.3 (1993)
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