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Effects of Calcium Channel Blockers on Sodium-Free Contracture in Atrial Muscle of the Rabbit

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dc.contributor.authorChoi, Eun Kyung-
dc.contributor.authorHan, Jin-
dc.contributor.authorKim, Eui Yang-
dc.contributor.authorEarm, Yung E-
dc.identifier.citationSeoul J Med, Vol.34 No.3, pp. 165-172-
dc.description.abstractEffects of organic and inorganic Ca-channel blockers on Na-Ca
exchange system were investigated in the rabbit atrial muscle. Atrial muscle strips
were perfused with Kr-free Tyrode solution in order to depress the sodium pump
activity. Removal of external sodium(sodium being replaced by Tris) induced a
contracture which reached a maximum after 1 min and effects of Ca-channel
blockers on the magnitude of contracture were analysed. The results obtained
were as follows: 1. In the concentrations of 30 pM, 100 pM and 300 ,uM Mn2 +
increased the magnitude of Na-removal contracture, but decreased it in the concentration
above 2 ,uM. Verapamil(IO-6 M) pretreatment did not alter the effect of
Mn2+ on sodium-removal contracture. 2. La3+, as Mn2+, increased the magnitude
of contracture in the concentrations of 30-300 pM, and decreased the contracture
in higher concentrations(> 1 mM) more prominently than Mn2+ did. 3. 0-600
also increased the contracture in the concentrations of 5 x 10-8 M, 10-7 M and 5
x 10-7 M but had no effect in higher concentratlonsfl Orf - 10-5 M), On the other
hand diltiazem had no dffect on the contracture in a wide range of concentrations
(up to 10-4 M). From the above results, it is concluded that Mn2+, La3+ and 0600
in lower concentrations stimulate the Na-Ca exchange system, whereas,
Mn2+, La3+ and 0-600 in higher concentrations depress the exchange system and
that Na-Ca exchange might be regulated by Ca-channel blockers and this regulation
is sensitive to the concentration of Ca-channel blockers.
dc.publisherSeoul National University College of Medicine-
dc.subjectCa-channel blockers-
dc.subjectSodium-calcium exchange-
dc.subjectRabbit atrial muscle-
dc.subjectSodium removal contracture-
dc.titleEffects of Calcium Channel Blockers on Sodium-Free Contracture in Atrial Muscle of the Rabbit-
dc.typeSNU Journal-
dc.citation.journaltitle서울 의대 잡지-
dc.citation.journaltitle서울 의대 학술지-
dc.citation.journaltitleSeoul Journal of Medicine-
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