S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 34 No.3 (1993)
An Antiproteinase lnhibits High Carbohydrate-Diet Induced Gallstone Formation in Hamsters
- Kim, Sun Whe; Choi, Jae Woon; Suh, Kyung Suk; Park, Yong Hyun
- Issue Date
- Seoul J Med, Vol.34 No.3, pp. 187-194
- High carbohydrate(CHO) diet plays a role in pigment gallstone formation,
though the mechanism is not yet clarified. We postulated that high CHO
diet induces gallstone formation through a mechanism whereby high CHO diet
poorly stimulates cholecystokinin(CCK) release and causes relative bile stasis.
The purpose of our study was to examine whether camostat mesilate(camostat),
oral antiproteinase increasing CCK release, inhibits gallstone formation from
high CHO diet in hamsters. Fifty six hamsters were divided into 3 groups(G): I(n =
18) was fed normal rat chow(43% CHO), lI(n = 19) was fed a high CHO diet(65%
CHO), III(n = 19) was fed 0.2% camostat high CHO diet. The animals were sacrificed
after 8 weeks. Stones were checked grossly and gallbladder bile was analysed.
Gallstones had developed in 11.1% of G-I, 84.2% of G-II, and 26.3% of GIII(
p < 0.05: II vs III). Concentrations of cholesterol, phospholipid, calcium, bilirubin
and bile acid were low in G-III. Pancreatic weight, reflecting chronic status of
CCK level, of G-II1 was greater than other groups and that of G-II was smaller
than that of G-I. In conclusion, camostat inhibits high CHO diet induced gallstone
formation in hamsters and the possible mechanism is that camostat recovers the
low CCK release by high CHO diet. This study suggests that high CHO diet is
associated with pigment stone formation through the mechanism that high CHO
diet causes poor CCK release.